An antigen-driven B-cell response within the salivary glands of patients with Sjögren’s syndrome [PDF]
Infection with a bacterium or virus induces the production of antibodies, specialised protein molecules that bind to and eliminate the microorganism.
Berek, C., Stott, D.I.
core +8 more sources
The identification and characterisation of key genes involved in somatic embryogenesis in wheat (Triticum, aestivum L.) [PDF]
One of the most remarkable aspects of plants cells is that on application of the plant hormone auxin, they possess the unique ability to de-differentiate and return to embryonic development, via a process known as `somatic embryogenesis' (SE). On removal
Minogue, Ben Michael
core +7 more sources
Complex patterns of male germline instability and somatic mosaicism in myotonic dystrophy type 1 [PDF]
The genetic basis of myotonic dystrophy type 1 (DM1) is the expansion of a CTG repeat in the 3' untranslated region of DM1PK . Once into the disease range, the repeat becomes highly unstable and is biased toward expansion in both somatic and germline ...
Martorell, L. +7 more
core +8 more sources
Seasonal variations of milk production and quality of Mediterranean ewes in extremely warm weather conditions [PDF]
Starting from the assumption that the climatic conditions determine the quantity and quality of available forage on the pastures which is the largest source of nutrients of meal of sheep reared in coastal and island of Croatia, the aim of this research ...
Darija Bendelja Ljoljić +4 more
doaj +1 more source
The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus [PDF]
In systemic lupus erythematosus (SLE) it has been hypothesized that self-reactive B cells arise from virgin B cells that express low-affinity, nonpathogenic germline V genes that are cross-reactive for self and microbial antigens, which convert to high ...
Stott, DI +11 more
core +1 more source
Reprogramming somatic cells into stem cells [PDF]
Abstract Recent scientific achievements in cell and developmental biology have provided unprecedented opportunities for advances in biomedical research. The demonstration that fully differentiated cells can reverse their gene expression profile to that of a pluripotent cell, and the successful derivation and culture of human embryonic
Ramiro, Alberio +2 more
openaire +2 more sources
Interspecies somatic cell nuclear transfer is dependent on compatible mitochondrial DNA and reprogramming factors [PDF]
Interspecies somatic cell nuclear transfer (iSCNT) involves the transfer of a nucleus or cell from one species into the cytoplasm of an enucleated oocyte from another.
St. John Justin C. +22 more
core +2 more sources
Stem cells of Hydra magnipapillata can differentiate into somatic cells and germ line cells [PDF]
We investigated whether all stem cells of Hydra can differentiate both somatic cells and gametes or if a separate germ line exists in these phylogenetically old organisms.
Bosch, Thomas C. G., David, Charles N.
core +1 more source
Gonadal somatic cells are the main players in gonad development and are important for sex determination and germ cell development. Here, using a time-series single-cell RNA sequencing (scRNA-seq) strategy, we analyzed fetal germ cells (FGCs) and gonadal ...
Rui Wang +9 more
doaj +1 more source
RNA interference is responsible for reduction of transgene expression after Sleeping Beauty transposase mediated somatic integration. [PDF]
Integrating non-viral vectors based on transposable elements are widely used for genetically engineering mammalian cells in functional genomics and therapeutic gene transfer.
Anja Ehrhardt +7 more
core +2 more sources

