Results 141 to 150 of about 1,861,621 (385)

Interpretation of the role of germline and somatic non-coding mutations in cancer: expression and chromatin conformation informed analysis [PDF]

, 2022
Michael Pudjihartono, Jo K. Perry, Cristin G. Print, Justin M. O’Sullivan, William Schierding   +4 more
openalex   +1 more source

Convergent somatic mutations in metabolism genes in chronic liver disease

Nature, 2021
Stanley W. K. Ng, F. Rouhani, Simon F. Brunner, Natalia Brzozowska, Sarah J. Aitken, Ming Yang, F. Abascal, L. Moore, Efterpi Nikitopoulou, L. Chappell, D. Leongamornlert, A. Ivovic, Philip S. Robinson, T. Butler, M. Sanders, N. Williams, Tim H. H. Coorens, J. Teague, K. Raine, A. Butler, Y. Hooks, B. Wilson, Natalie Birtchnell, Huw W. Naylor, S. Davies, M. Stratton, I. Martincorena, R. Rahbari, C. Frezza, M. Hoare, P. Campbell   +30 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Early detection of colorectal cancer somatic mutations using cfDNA liquid biopsies in a murine carcinogenesis model [PDF]

, 2022
Héctor Martínez-Gregorio, Clara Estela Díaz-Velásquez, Mario Romero-Piña, Miguel Ruiz de la Cruz, Norma L. Delgado‐Buenrostro, Aldo de la Cruz-Montoya, Yolanda I. Chirino, Luis I. Terrazas, Luis A. Medina, Felipe Vaca‐Paniagua   +9 more
openalex   +1 more source

The prognostic effects of somatic mutations in ER-positive breast cancer

Nature Communications, 2017
Here we report targeted sequencing of 83 genes using DNA from primary breast cancer samples from 625 postmenopausal (UBC-TAM series) and 328 premenopausal (MA12 trial) hormone receptor-positive (HR+) patients to determine interactions between somatic ...
O. Griffith, N. Spies, M. Anurag, M. Griffith, Jingqin R Luo, D. Tu, B. Yeo, J. Kunisaki, Christopher A. Miller, K. Krysiak, J. Hundal, Benjamin J. Ainscough, Zachary L. Skidmore, Katie M. Campbell, Runjun D. Kumar, C. Fronick, L. Cook, J. Snider, S. Davies, Shyam M. Kavuri, E. Chang, V. Magrini, D. Larson, R. Fulton, Shuzhen Liu, S. Leung, D. Voduc, R. Bose, M. Dowsett, R. Wilson, T. Nielsen, E. Mardis, M. Ellis   +32 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Interpretation of somatic POLE mutations in endometrial carcinoma

Journal of Pathology, 2019
Pathogenic somatic missense mutations within the DNA polymerase epsilon (POLE) exonuclease domain define the important subtype of ultramutated tumours (‘POLE‐ultramutated’) within the novel molecular classification of endometrial carcinoma (EC). However,
A. Léon-Castillo, H. Britton, M. McConechy, J. McAlpine, R. Nout, S. Kommoss, S. Brucker, Joseph Carlson, E. Epstein, T. Rau, T. Bosse, D. Church, C. Gilks   +12 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Clearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia.

Journal of Clinical Oncology, 2018
Purpose The aim of the current study was to determine whether the degree of mutation clearance at remission predicts the risk of relapse in patients with acute myeloid leukemia (AML).
Kiyomi Morita, H. Kantarjian, Feng Wang, Yuanqing Yan, C. Bueso-Ramos, K. Sasaki, G. Issa, Sa A. Wang, J. Jorgensen, Xingzhi Song, Jianhua Zhang, S. Tippen, Rebecca L. Thornton, Marcus Coyle, L. Little, C. Gumbs, N. Pemmaraju, Naval G. Daver, C. Dinardo, M. Konopleva, M. Andreeff, F. Ravandi, J. Cortes, T. Kadia, E. Jabbour, G. Garcia-Manero, K. Patel, P. Futreal, Koichi Takahashi   +28 more
semanticscholar   +1 more source