Results 291 to 300 of about 199,006 (315)
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Journal of Toxicology and Environmental Health, 1980
The evidence is reviewed that supports the role of genetic lesions in carcinogenesis; such lesions may be initiating events in the multistep process leading to clinically detectable tumor. Other possible manifestations of alterations in the hereditary material of somatic cells are discussed; DNA damage may lead to benign tumors responsible for ...
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The evidence is reviewed that supports the role of genetic lesions in carcinogenesis; such lesions may be initiating events in the multistep process leading to clinically detectable tumor. Other possible manifestations of alterations in the hereditary material of somatic cells are discussed; DNA damage may lead to benign tumors responsible for ...
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Current Opinion in Immunology, 1993
The germinal center plays a crucial role in the development of the memory B cell. The repertoire of the antigen-specific B cell is shaped in this microenvironment. Self-specific B cells escaping normal regulation may develop into high affinity pathogenic Ig-producing cells.
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The germinal center plays a crucial role in the development of the memory B cell. The repertoire of the antigen-specific B cell is shaped in this microenvironment. Self-specific B cells escaping normal regulation may develop into high affinity pathogenic Ig-producing cells.
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Problems of somatic mutation and cancer [PDF]
BioEssays, 2004 AbstractSomatic mutation plays a key role in transforming normal cells into cancerous cells. The analysis of cancer progression therefore requires the study of how point mutations and chromosomal mutations accumulate in cellular lineages. The spread of somatic mutations depends on the mutation rate, the number of cell divisions in the history of a ...
Steven A. Frank, Martin A. Nowak
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Germline and somatic mutations in meningiomas
Cancer Genetics, 2015Meningiomas arise from the arachnoid layer of the meninges that surround the brain and spine. They account for over one third of all primary central nervous system tumors in adults and confer a significant risk of location-dependent morbidity due to compression or displacement.
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Somatic mutations and the hierarchy of hematopoiesis
BioEssays, 2010AbstractClonal disease is often regarded as almost synonymous with cancer. However, it is becoming increasingly clear that our bodies harbor numerous mutant clones that are not tumors, and mostly give rise to no disease at all. Here we discuss three somatic mutations arising within the hematopoietic system: BCRâABL, characteristic of chronic myeloid ...
Jorge M. Pacheco +3 more
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Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1987
Abstract The mechanisms of gene and chromosomal mutagenesis in higher plants are not yet fully understood. As with bacterial cells, a wide variety of studies using inhibitors of DNA repair and replication has suggested that errors in DNA replication and DNA repair are involved in mutagenesis.
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Abstract The mechanisms of gene and chromosomal mutagenesis in higher plants are not yet fully understood. As with bacterial cells, a wide variety of studies using inhibitors of DNA repair and replication has suggested that errors in DNA replication and DNA repair are involved in mutagenesis.
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Somatic Mutations in Aplastic Anemia
Hematology/Oncology Clinics of North America, 2018Aplastic anemia (AA) is an immune-mediated disorder that overlaps closely with clonal disorders, such as myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria (PNH). PIGA mutations in PNH clones and functional loss of HLA, including structural HLA mutations, likely represent immune escape clones and correlate with response to ...
Mufti, Ghulam J., Marsh, Judith C.W.
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Somatic mutations and ageing in silico
Mechanisms of Ageing and Development, 2003Considerable evidence points to an accumulation of somatic mutations in older cells and organisms but the causal role of mutations in the ageing process is still unclear. In addition to demonstrating that mutations accumulate, it is important to address the question of whether they do so at a sufficient rate and with a dynamic profile that is ...
Thomas B. L. Kirkwood, Carole J. Proctor
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2017
Somatic mutations in patient tumor DNA samples can be readily detected based on mass spectrometry. The MassARRAY system is a high-throughput matrix-assisted laser desorption time-of-flight (MALDI) mass spectrometer for detection of nucleic acids. The technique is based on single-nucleotide base extension.
Robert Cummins, Anthony O'Grady
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Somatic mutations in patient tumor DNA samples can be readily detected based on mass spectrometry. The MassARRAY system is a high-throughput matrix-assisted laser desorption time-of-flight (MALDI) mass spectrometer for detection of nucleic acids. The technique is based on single-nucleotide base extension.
Robert Cummins, Anthony O'Grady
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Somatic Hypermutation: A Mutational Panacea
2004Publisher Summary This chapter discusses activation-induced deaminase (AID), which was discovered using a subtractive hybridization screen for genes activated on induction of class switch recombination (CSR). AID expression is restricted to activated B cells and is required for somatic hypermutation (SHM) in mice.
Phuong Pham +3 more
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