Results 301 to 310 of about 199,006 (315)

Somatic Mutations and Aging

1978
Somatic mutations have been a major focus of aging research for many years. Initial support for the view that aging in mammals was due to the accumulation of somatic mutations was the effect of radiation on life span (Prasad, 1974). This mutagenic effect of radiation has been established in several systems, including mammalian cells (Awa, 1975).
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Neonatal Immunity and Somatic Mutation

International Reviews of Immunology, 2000
Neonatal animals are able to mount an effective immune response, both humoral and cellular, when immunized using conditions that maximize stimulation of antigen presenting cells, T cells, and B cells. In adults, somatic mutation is a key feature of the humoral immune response because it contributes to the generation of high affinity memory B cells ...
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Somatic Mutation and Antibody Diversity

Pathology and Immunopathology Research, 1984
Nucleotide insertions or deletions determine novel amino acid sequences at the VH-D and D-JH junction sites. Since these cannot be predicted by known coding genes, they are regarded as a form of somatic mutagenesis. A second type of somatic mutation in Ig structural genes are the stochastic base substitutions that have now been found in both V region ...
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Somatic Mutations in the Apple

Science, 1943
J. K. Shaw, L. Southwick
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Mutation: Somatic Mutation, Cancer, and Aging

1997
Mutations may also occur in somatic cells. The effect of a somatic mutation is found in the descendants of the mutant cell, making the individual a mosaic. Mosaics are individuals with a mixed cell population. In the simplest situation a normal cell population and a mutant cell population may coexist in a single individual.
Arno G. Motulsky, h.c. Friedrich Vogel
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Somatic mutations

Nature, 1978
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Somatic mutations in lymphoma

Pathology, 1984
Alec Morley, John L. Dempsey, Ram Seshadri   +2 more
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Somatic mutations and ageing

Mutation Research/Reviews in Mutation Research, 2000
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Somatic hotspot mutations in APA [PDF]

Nature Reviews Endocrinology, 2013
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Somatic mutations and cellular aging

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1993
J.A. Gossen, J. Vijg
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