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Somatic mutations and proteins
Proceedings of the Royal Society of London. Series B. Biological Sciences, 1966A large body of data has now been accumulated concerning the ways in which heritable mutations can affect protein structure. Such mutations are usually presumed to arise in the germ line, and are studied by progeny analyses of various types.
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Current Opinion in Immunology, 1993
The germinal center plays a crucial role in the development of the memory B cell. The repertoire of the antigen-specific B cell is shaped in this microenvironment. Self-specific B cells escaping normal regulation may develop into high affinity pathogenic Ig-producing cells.
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The germinal center plays a crucial role in the development of the memory B cell. The repertoire of the antigen-specific B cell is shaped in this microenvironment. Self-specific B cells escaping normal regulation may develop into high affinity pathogenic Ig-producing cells.
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Lineage tracing of human development through somatic mutations
Nature, 2021M. Spencer Chapman +15 more
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Somatic Mutations in Aplastic Anemia
Hematology/Oncology Clinics of North America, 2018Aplastic anemia (AA) is an immune-mediated disorder that overlaps closely with clonal disorders, such as myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria (PNH). PIGA mutations in PNH clones and functional loss of HLA, including structural HLA mutations, likely represent immune escape clones and correlate with response to ...
Mufti, Ghulam J., Marsh, Judith C.W.
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Genetic testing in prostate cancer management: Considerations informing primary care
Ca-A Cancer Journal for Clinicians, 2022Veda N Giri +2 more
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Modern developments in germline pharmacogenomics for oncology prescribing
Ca-A Cancer Journal for Clinicians, 2022Natalie M Reizine, Peter H O'donnell
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