Results 51 to 60 of about 49,786 (271)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Sposoby klasyfikowania zaburzeń psychosomatycznych

Psychiatria i Psychologia Kliniczna, 2018
Klasyfikowanie zaburzeń psychosomatycznych, mimo istnienia i powszechnego stosowania systemów klasyfikacyjnych, nie jest ujednolicone i niejednokrotnie przysparza trudności diagnostycznych.
Agnieszka Woźniewicz
doaj   +1 more source

Somatic symptom disorder in dermatology

, 2017
Somatic symptom disorder (SSD) is defined by the prominence of somatic symptoms associated with abnormal thoughts, feelings, and behaviors related to the symptoms, resulting in significant distress and impairment.
Levenson, James L., Sharma, Aditi A., Ortega-Loayza, Alex G.   +2 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Comparative evaluation of psychopathological characteristics, alexithymia, and quality of life in adolescents with somatic symptom disorder and functional neurological symptom disorder

Klinik Psikiyatri Dergisi
INTRODUCTION: Somatic Symptom Disorder (SSD) and Functional Neurological Symptom Disorder (FNSD) are common presentations of somatic symptom and related disorders in adolescence. Despite shared emotional and functional impairments, these disorders differ
Makbule Esen Öksüzoğlu, Hande Günal Okumuş, Huriye Berna Devecioğlu, Yusuf Selman Çelik, Sema Eraslan, Setenay Adıgüzel   +5 more
doaj   +1 more source

Psychometric Properties of the Bermond–Vorst Alexithymia Questionnaire (BVAQ) in the General Population and a Clinical Population

Frontiers in Psychiatry, 2018
IntroductionThe Bermond–Vorst Alexithymia Questionnaire (BVAQ) has been validated in student samples and small clinical samples, but not in the general population; thus, representative general-population norms are lacking.AimWe examined the factor ...
Lars de Vroege, Lars de Vroege, Wilco H. M. Emons, Klaas Sijtsma, Christina M. van der Feltz-Cornelis, Christina M. van der Feltz-Cornelis   +5 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Study design of the Routine Outcome Monitoring for Geriatric Psychiatry & Science (ROM-GPS) project; a cohort study of older patients with affective disorders referred for specialised geriatric mental health care

BMC Psychiatry, 2019
Background Affective disorders, encompassing depressive-, anxiety-, and somatic symptom disorders, are the most prevalent mental disorders in later life.
Richard C. Oude Voshaar, Ton D. F. Dhondt, Mario Fluiter, Paul Naarding, Sanne Wassink, Maureen M. J. Smeets, Loeki P. R. M. Pelzers, Astrid Lugtenburg, Martine Veenstra, Radboud M. Marijnissen, Gert-Jan Hendriks, Lia A. Verlinde, Robert A. Schoevers, Rob H. S. van den Brink   +13 more
doaj   +1 more source

The clinical inadequacy of the DSM-5 classification of somatic symptom and related disorders: an alternative trans-diagnostic model

, 2016
The Diagnostic and Statistical of Mental Disorders, Fifth Edition (DSM-5) somatic symptom and related disorders chapter has a limited clinical utility.
FAVA, GIOVANNI ANDREA, Cosci, Fiammetta
core   +1 more source