Results 171 to 180 of about 9,088,320 (244)

Single human fingertip mechanoreceptive afferents simultaneously encode multidimensional aspects of touch

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Mechanoreceptors in the fingertip skin allow us to explore objects and to feel a vast range of textures. We recorded responses from individual low‐threshold mechanoreceptive afferents in humans while dynamic stimuli were swept across their receptive fields, systematically varying force, velocity and spatial period.
Victoria Ashley Lang   +3 more
wiley   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise   +2 more
wiley   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Low‐threshold cutaneous mechanoreceptors on the foot sole have enhanced sensitivity when skin temperature is elevated

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of microneurography recordings used to examine the effects of local skin heating on cutaneous mechanoreceptor responses in the human foot (left panel). A microelectrode inserted into a peripheral nerve records single‐unit activity from tactile afferent fibres while controlled mechanical stimuli are applied ...
Erika E. Howe   +4 more
wiley   +1 more source

Diving into the unknown: Evidence of enhanced skeletal muscle lactate efflux potential and blood–muscle exchange in competitive breath‐hold divers

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Competitive breath‐hold divers exhibit skeletal muscle characteristics indicative of enhanced blood‐muscle exchange capacity and increased lactate efflux potential. Top left: Participant characteristics, matched for age, height, body mass, and maximal oxygen uptake (V̇O2max${\dot{\mathrm{V}}}\rm{O}_{\rm{2max}}$).
Antonis Elia   +7 more
wiley   +1 more source

Breathing‐evoked potentials in humans during wakefulness and sleep

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Quiet natural breathing at rest elicits structured breathing‐evoked potentials (BEPs) detectable in scalp EEG. Left, respiratory cycles were identified from the nasal pressure signal and used to time‐lock EEG averaging. Right, the resulting BEPs persist across wakefulness and all sleep stages, including non‐rapid eye movement ...
Léo Grassion   +9 more
wiley   +1 more source

Distinct neural input strategies to motor units in the soleus and medial gastrocnemius during quiet standing

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Motor unit spike trains were decomposed from high‐density surface electromyograms recorded from the medial gastrocnemius (MG; left, in red) muscle and soleus (SOL; right, in blue). To compare the neural input to the spinal motoneurons between them, we quantified the intramuscular coherence (IMC) of motor unit spike trains within ...
Hiroki Arakawa   +4 more
wiley   +1 more source

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