Results 211 to 220 of about 67,778 (294)

Early Prediction of Neurological Outcome After Cardiac Arrest‐Rationale and Design of the Prospective International Observational EARLY‐NEURO, a STEPCARE Substudy

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 5, May 2026.
ABSTRACT Background Guidelines discourage prediction of neurological outcome in comatose patients within the first 72 h after cardiac arrest. Increasing evidence suggests that patients with the most severe brain injury and those with no or minimal brain injury may be identified before 72 h using novel methods.
Marion Moseby‐Knappe, Erik Westhall, Marjolein Admiraal, Margareta Lang, Helena Levin, Johanna Hästbacka, Marjaana Tiainen, Markus Skrifvars, Gisela Lilja, Janus C. Jacobsen, Alice Lagebrant, Matt Wise, Matti Reinikainen, Paul Young, Manoj Saxena, Simon Schmidbauer, Naomi Hammond, Frances Bass, Ameldina Ceric, Caroline Kamp, Christina Sillassen, Christoph Leithner, Pascal Stammet, Matthias P. Hilty, Pedro D. Wendel‐Garcia, Georg Royl, Tobias Graf, Matt Thomas, Katie Sweet, Stepani Bendel, Joonas Tirkkonen, Annerose Mengel, Maria‐Ioanna Stefanou, Luis Georg Romundstad, Philipp Seidel, Jessica Kåhlin, Jonathan Grip, Jonna Heinonen, Rakesh H. Jadav, Jens Nee, Daniela Nowak, Matthias Hänggi, Johan Undén, Anna Lybeck, Joachim Düring, Martin Kenda, Jesper Johnsson, Niklas Nielsen, Tobias Cronberg   +48 more
wiley   +1 more source

Cortical integration of tactile inputs distributed across timescales. [PDF]

Imaging Neurosci (Camb)
Wan W, Ridderinkhof KR, Ghosh A.
europepmc   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Displacement-Guided Focused Ultrasound of the Median Nerve Modulates Somatosensory Evoked Potentials in Humans. [PDF]

IEEE Trans Biomed Eng
McCune EP, Blackman SG, Kamimura HAS, Bendau EV, Sachs TD, Kim S, Lee SA, Winfree CJ, Konofagou EE.   +8 more
europepmc   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Investigating the effects of TMS-related somatosensory inputs on TMS-evoked potentials provides evidence against significant interaction. [PDF]

Sci Rep
Gordon PC, Metsomaa J, Belardinelli P, Ziemann U.   +3 more
europepmc   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

British Journal of Pharmacology, Volume 183, Issue 10, Page 2307-2323, May 2026.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert, Chantal Fitterer, Sylvain Hugel, Mila Jesic, Yannick Goumon, Virgine Andry, Severine Schneider, Francois Daubeuf, Abdelfattah Faouzi, Stephane Doridot, Susruta Majumdar, Frederic Bihel, Martine Schmitt, Dominique Massotte   +13 more
wiley   +1 more source

Somatosensory Induced Cerebellar Responses to Peripheral Nerve Stimulation: A Time and Time-Frequency EEG Study. [PDF]

Brain Sci
Latorre A, Humaidan K, Sanna M, Lavena ML, Contu AM, Mele MG, Casula EP, Rocchi L.   +7 more
europepmc   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2324-2340, May 2026.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Diagnostic value of somatosensory evoked potentials for paroxysmal sympathetic hyperactivity: a retrospective cohort study. [PDF]

Front Neurol
Liu L, Han Y, Feng H, Feng H, Chen F, Fu J.   +5 more
europepmc   +1 more source