Results 251 to 260 of about 301,779 (333)

GluN2C/D‐containing NMDA receptors enhance temporal summation and increase sound‐evoked and spontaneous firing in the inferior colliculus

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Here, we find that GluN2D‐containing NMDA receptors (NMDARs) are expressed by most vasoactive intestinal peptide neurons in the inferior colliculus (IC). These receptors are less susceptible to Mg2+ blockade compared to GluN2A/B‐containing NMDARs, allowing ions to flow at resting membrane potential.
Audrey C. Drotos   +3 more
wiley   +1 more source

Control of action potential afterdepolarizations in the inferior olive by inactivating A‐type currents through KV4 channels

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend KV4 channel availability regulates inferior olive action potential duration. The durations of action potentials in inferior olive neurons (blue) depend strongly on preceding membrane potential, with afterdepolarizations varying over the physiological range by almost two orders of magnitude (open circles). Voltage clamp recordings
Ziyad W. Sultan   +2 more
wiley   +1 more source

Adenine nucleotide translocator and ATP synthase cooperate in mediating the mitochondrial permeability transition

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Both ATP synthase and adenine nucleotide translocator (ANT) play key roles in mediating the permeability transition. The contribution of ANT becomes evident in the presence of atractylate (ATR) at pH 6.5, a condition that prevents ATP synthase channel activity. At pH 7.4, this effect is minimal, suggesting a critical role for ATP
Ludovica Tommasin   +7 more
wiley   +1 more source

Paired corticospinal‐motoneuronal stimulation enhances ballistic motor learning and corticospinal plasticity in older adults

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The first part of this experimental study showed that late adulthood (adults aged 65–75 years) is associated with reduced motor performance and learning of simple vigorous finger movements. The second part of the study shows that ballistic motor learning can be improved in older adults when a practice session is preceded by a ...
Jonas Rud Bjørndal   +5 more
wiley   +1 more source

Corticothalamic modulation of somatosensory thalamic tactile processing

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend To examine how Layer 6 drug application affects ventral‐posterior‐medial (VPm) responses, we recorded local field potentials and single‐unit activity from barrels adjacent to the drug application site during spontaneous and tactile stimulation.
Avisar Einav, Rony Azouz
wiley   +1 more source

Heartbeat‐related activity in the anterior thalamus differs between phasic and tonic REM sleep

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Periods of rapid eye movement (REM) sleep with or without ocular activity (phasic and tonic REM, respectively), as well as quiet wakefulness of comparable duration were contrasted in terms of interoceptive processing at the thalamic level. Eleven epilepsy patients involved in an anterior thalamus (ANT) deep brain stimulation (DBS)
Péter Simor   +7 more
wiley   +1 more source

The apical mucus layer alters the pharmacological properties of the airway epithelium

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In the airway epithelium, the cAMP‐activated cystic fibrosis transmembrane conductance regulator (CFTR) channel is a major pathway for chloride secretion. Its activity can potentially be evaluated by measuring the extent of chloride flux inhibition elicited by CFTR blockers, such as CFTRinh‐172 and PPQ‐102.
Daniela Guidone   +5 more
wiley   +1 more source

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