Results 261 to 270 of about 301,779 (333)

Balance control threshold to vestibular stimuli

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend (A) We exposed participants standing on force plates to sinusoidal electrical vestibular stimulation (EVS) at varying amplitudes (0.2, 0.4, 0.6 mA) and frequencies (0.1, 0.2, 0.5, 1 Hz). (B) Given the role of internal head motion estimates in generating balance‐correcting responses, we used signal detection theory to quantify non‐
Martin Simoneau   +2 more
wiley   +1 more source

Muscle Strengthening Exercises for the Foot and Ankle: A Scoping Review Exploring Adherence to Best Practice for Optimizing Musculoskeletal Health

open access: yesJournal of Foot and Ankle Research, Volume 18, Issue 2, June 2025.
ABSTRACT Background Foot and ankle muscle strengthening exercises are common interventions for many musculoskeletal conditions that are associated with pain and limited function in the lower limb. The scientific literature has a multitude of strengthening exercises recommended, and they have been criticized for not adhering to best practice and for ...
John W. A. Osborne   +4 more
wiley   +1 more source

Association Between Interoceptive Accuracy and Pain Perception: Insights From Trained Musicians and Athletes

open access: yesEuropean Journal of Pain, Volume 29, Issue 5, May 2025.
ABSTRACT Background The integration of concurrent endogenous and exogenous multisensory information throughout years of dedicated sensorimotor training is associated with enhanced interoceptive accuracy and altered pain perception in healthy individuals.
Boris Kleber   +4 more
wiley   +1 more source

GABAB Receptor: Structure, Biological Functions, and Therapy for Diseases

open access: yesMedComm, Volume 6, Issue 5, May 2025.
Within the GABAergic system, GABABRs are potential therapeutic targets for dealing multiple metabolic and binge eating disorders and food addiction. Allosteric modulators and small peptides targeting GABABR signaling pathways may be developed as attractive drug candidates that avoid the side effects of agents that directly bind these receptors ...
Weijie Xie   +10 more
wiley   +1 more source

Dysregulation of Astrocytic ATP/Adenosine Release in the Hippocampus Cause Cognitive and Affective Disorders: Molecular Mechanisms, Diagnosis, and Therapy

open access: yesMedComm, Volume 6, Issue 5, May 2025.
Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes   +4 more
wiley   +1 more source

An overview of the non‐procedural treatment options for peripheral neuropathic pain

open access: yesMuscle &Nerve, Volume 71, Issue 5, Page 791-801, May 2025.
Abstract Peripheral neuropathic pain is common in patients with peripheral nerve injury and can significantly impact both their function and quality of life. There is a wide variety of non‐interventional treatment approaches, including pharmacologic therapy, physical/occupational therapy, modalities (therapeutic, mechanical, thermal, etc.), psychology,
Evan R. Zeldin   +6 more
wiley   +1 more source

Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease

open access: yesAdvanced Science, Volume 12, Issue 14, April 10, 2025.
NeuroD1 mediates brain‐wide astrocyte‐to‐neuron gene therapy conversion in 5xFAD mouse brain. Regenerated neurons can fire action potentials and integrate into pre‐existing neural networks, ultimately improving cognition in AD mice. Abstract Alzheimer's disease (AD) is a progressive and irreversible brain disorder with extensive neuronal loss in the ...
Zheng Wu   +10 more
wiley   +1 more source

Effects of Cerebellar Transcranial Magnetic Stimulation on the Motor Function of Patients With Stroke: A Systematic Review and Meta‐Analysis

open access: yesBrain and Behavior, Volume 15, Issue 4, April 2025.
cTMS can effectively improve the motor function of patients with stroke, with significant efficacy in balance and limb motor function. The therapeutic effect of cTMS was more pronounced when intervening in the subacute phase, and when the excitatory stimulation mode and moderate intensity (≤ 80% RMT) were used.
Yongxin Zhu   +7 more
wiley   +1 more source

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