Results 181 to 190 of about 4,123 (255)

A Serverless Pharmacogenomic Risk Dashboard: Translating Ensemble Models and Model‐Based Scenario Rules to Clinical Decision Support

open access: yesClinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT The “last mile” problem in healthcare AI—translating high‐performance models into accessible, privacy‐preserving point‐of‐care tools—remains unsolved for pharmacogenomic (PGx) risk assessment. No existing platform integrates opioid and polypharmacy risk scoring, model‐based scenario analysis, and CPIC‐based PGx patient cards within a single ...
R. Jerome Dixon, Elvin T. Price
wiley   +1 more source

Thinking Is Not Enough: The B* Expansion Technique for Enhancing Autonomous LLM Agents

open access: yesExpert Systems, Volume 43, Issue 8, August 2026.
ABSTRACT Most autonomous agents built on large language models (LLMs) focus on improving internal reasoning while assuming a fixed and complete set of primitive actions. In this work, we challenge this assumption and introduce the B*$$ {B}^{\ast } $$ expansion technique, an action‐centric method that enables agents to iteratively construct new actions ...
Sebastián Andrés Mayorquín Posadas   +1 more
wiley   +1 more source

A Revised Classification Framework for Studies in Systematic Reviews: Prioritizing Outcome Data Availability Over Study Status

open access: yesJournal of Evaluation in Clinical Practice, Volume 32, Issue 5, August 2026.
ABSTRACT Background The classification of primary studies is a critical methodological step in the conduct of systematic reviews. The current Cochrane approach categorizes studies as ‘included’, ‘excluded’, ‘ongoing’ or ‘awaiting classification’, primarily based on study eligibility and completion status.
Rafael Leite Pacheco, Rachel Riera
wiley   +1 more source

Collectivism and Suicide Risk: Reinterpreting Interpersonal Theory Constructs in Southern Belize

open access: yesSuicide and Life-Threatening Behavior, Volume 56, Issue 4, August 2026.
ABSTRACT Background Over 70% of global suicides occur in low‐ and middle‐income countries (LMICs), yet cultural mechanisms of suicide risk remain underexplored. Collectivism is often assumed protective, but emerging evidence from vertically collectivist settings suggests a more complex relationship. Methods Qualitative interviews were conducted with 29
Jaclyn Kirsch   +3 more
wiley   +1 more source

CaV1.2 dynamics in native male arterial myocytes

open access: yesThe Journal of Physiology, Volume 604, Issue 15, Page 6302-6323, 1 August 2026.
Abstract figure legend Proposed model of microtubule‐dependent CaV1.2 reorganization in vascular disease. Schematic illustration of microtubule‐mediated delivery and stabilization of CaV1.2 channels into enlarged plasma membrane clusters in response to Ang II or hyperglycaemia, promoting cooperative gating and enhanced Ca2+ influx. Abstract L‐type CaV1.
Miguel Martin‐Aragon Baudel   +9 more
wiley   +1 more source

Evidence that S‐phase kinase associated protein 2 (SKP2) is ubiquitinated and degraded via a Rho‐related BTB domain containing 1 (RhoBTB1) and Cullin‐3 mechanism in placenta

open access: yesPhysiological Reports, Volume 14, Issue 15, August 2026.
Graphical representation of mechanism by which RhoBTB1 regulates SKP2. Abstract Rho related BTB domain containing 1 (RhoBTB1) is highly expressed in placenta and functions to deliver protein targets to the Cullin‐3 (CUL3) E3 ubiquitin ligase where they are targeted for ubiquitination and degradation.
Alina L. Tvina   +11 more
wiley   +1 more source

A comparative accuracy study of multimodal LLMs, VLM and agent-based framework for pulmonary nodule detection on chest radiographs. [PDF]

open access: yesFront Digit Health
Khovanova D   +5 more
europepmc   +1 more source

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