Results 141 to 150 of about 119,092 (211)

Activatable Cancer Sono‐Immunotherapy using Semiconducting Polymer Nanobodies

Advances in Materials, 2022
Despite the great promises of sonodynamic therapy (SDT) in combination cancer therapy, its clinical applications are hindered by the “always‐on” pharmacological activities of therapeutic agents and the lack of efficient sonosensitizers.
Ziling Zeng, Chi Zhang, Shasha He, Jingchao Li, Kanyi Pu   +4 more
semanticscholar   +1 more source

Endoplasmic Reticulum‐Targeting Iridium(III) Nanosonosensitizer Amplifies Immunogenic Cell Death for Boosted Tumor Sono‐Immunotherapy

Advanced Functional Materials
Reactive oxygen species (ROS)‐induced endoplasmic reticulum (ER) stress in sonodynamic therapy (SDT) can elicit immunogenic cell death (ICD)‐initiated antitumor immunity for augmented sono‐immunotherapy.
Xiaoyu Xu, Meixu Chen, Shan Jiang, Zhengyin Pan, Chunshun Zhao   +4 more
semanticscholar   +1 more source

An “Outer Piezoelectric and Inner Epigenetic” Logic‐Gated PANoptosis for Osteosarcoma Sono‐Immunotherapy and Bone Regeneration

Advances in Materials
The precise manipulation of PANoptosis, a newly defined cell death pathway encompassing pyroptosis, apoptosis, and necroptosis, is highly desired to achieve safer cancer immunotherapy with tumor‐specific inflammatory responses and minimal side effects ...
Xiaoting Wang, Xun Guo, Hongze Ren, Xinran Song, Liang Chen, Luodan Yu, Jianli Ren, Yu Chen   +7 more
semanticscholar   +1 more source

Ultrasound activatable microneedles for bilaterally augmented sono-chemodynamic and sonothermal antibacterial therapy.

Acta Biomaterialia, 2022
Chemodynamic therapy (CDT) employs Fenton catalysts to kill bacteria by converting hydrogen peroxide (H2O2) into toxic hydroxyl radical (•OH). Among them, Fenton-type metal peroxide nanoparticles fascinate nanomaterials with intriguing physiochemical ...
Manman Liang, L. Shang, Yixin Yu, Yujie Jiang, Q. Bai, Junchi Ma, Dongqin Yang, Ning Sui, Zhiling Zhu   +8 more
semanticscholar   +1 more source

Boosting Sono-immunotherapy of Prostate Carcinoma through Amplifying Domino-Effect of Mitochondrial Oxidative Stress Using Biodegradable Cascade-Targeting Nanocomposites.

ACS Nano
Sono-immunotherapy faces challenges from poor immunogenicity and low response rate due to complex biological barriers. Herein, we prepared MCTH nanocomposites (NCs) consisting of disulfide bonds (S-S) doped mesoporous organosilica (MONs), Cu-modified ...
Yandong Wang, Haodong Li, Guiming Niu, Yutang Li, Zhaoqin Huang, Shiqing Cheng, Keqin Zhang, Hui Li, Qiang Fu, Yanyan Jiang   +9 more
semanticscholar   +1 more source

Self-Catalyzed Sono-Photoinduced Arylation of Quinoxalin-2(1H)-ones with Arylhydrazines.

Journal of Organic Chemistry
Herein, the first example of self-catalyzed sono-photoinduced carbon-carbon bond formation was described. Combining the advantages of phototriggered self-catalysis and ultrasonic catalysis, a wide range of 3-arylquinoxalin-2(1H)-ones can be efficiently ...
Yao-Dan Xu, Yu Xing, Hongfu Ji, Li-Juan Ou, Weimin He, Jia Peng, Jia-Sheng Wang, Jun Jiang, Weimin He   +8 more
semanticscholar   +1 more source

Sono-photocatalytic degradation of tetracycline and pharmaceutical wastewater using WO3/CNT heterojunction nanocomposite under US and visible light irradiations: A novel hybrid system.

Journal of Hazardous Materials, 2020
In this paper, in-situ fabrication of tungsten oxide (WO3) on carbon nano-tube (CNT) was performed via sol-gel/hydrothermal method to prepare WO3/CNT nanocomposites and then coupled with visible light and ultrasound (US) irradiations for sono ...
Ali Akbar Isari, Mahya Mehregan, Shima Mehregan, F. Hayati, Roshanak Rezaei Kalantary, Babak Kakavandi   +5 more
semanticscholar   +1 more source

Semiconducting polymer nanoprodrugs enable tumor-specific therapy via sono-activatable ferroptosis.

Biomaterials
Ferroptosis, a recently identified form of cell death, holds promise for cancer therapy, but concerns persist regarding its uncontrolled actions and potential side effects.
Fengshuo Wang, Zhiting Wu, Yijing Zhang, Meng Li, Peng Wei, Tao Yi, Jingchao Li   +6 more
semanticscholar   +1 more source

Bimetal‐Biligand Frameworks for Spatiotemporal Nitric Oxide‐Enhanced Sono‐Immunotherapy

Advances in Materials
Sonodynamic therapy can trigger immunogenic cell death to augment immunotherapy, benefiting from its superior spatiotemporal selectivity and non‐invasiveness.
Yu Cheng, Wenbin Zhong, Yun Chen, Brynne Shu Ni Tan, Yue Zhao, Jingjing Guo, Mengmeng Ma, Yanli Zhao   +7 more
semanticscholar   +1 more source

Sono‐Controllable and ROS‐Sensitive CRISPR‐Cas9 Genome Editing for Augmented/Synergistic Ultrasound Tumor Nanotherapy

Advances in Materials, 2021
The potential of the cluster regularly interspaced short palindromic repeat (CRISPR)‐associated protein 9 (Cas9)‐based therapeutic genome editing is severely hampered by the difficulties in precise regulation of the in vivo activity of the CRISPR‐Cas9 ...
Yinying Pu, Haohao Yin, Caihong Dong, Huijing Xiang, Wencheng Wu, Bangguo Zhou, Dou Du, Yu Chen, Huixiong Xu   +8 more
semanticscholar   +1 more source