Results 61 to 70 of about 1,986 (208)

Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate [PDF]

Drug Delivery, 2019
The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL).
Wen Lin, Xiaoxing Ma, Chaopei Zhou, Hong Yang, Yang Yang, Xiangyang Xie, Chunrong Yang, Cuiyan Han   +7 more
openaire   +3 more sources

Nanostructured TiO2 cavitation agents for dual-modal sonophotocatalysis with pulsed ultrasound

Ultrasonics Sonochemistry, 2021
Current sonochemical methods rely on spatially uncontrolled cavitation for radical species generation to promote chemical reactions. To improve radical generation, sonosensitizers have been demonstrated to be activated by cavitation-based light emission (
U.S. Jonnalagadda, X Su, J.J. Kwan
doaj   +1 more source

ROS-Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A-Sonodynamic Therapy in THP-1 Macrophages [PDF]

, 2017
Monocyte-derived macrophages participate in infaust inflammatory responses by secreting various types of proinflammatory factors, resulting in further inflammatory reactions in atherosclerotic plaques.
Jiayuan Kou, Liming Yang, Xiaobo Han, Xuesong Li, Ye Tian, Yinghong Zheng, Yueqing Jiang, Zhaoyu Zhong, Zhongni Liu   +8 more
core   +2 more sources

Photo-sonodynamic combination activity of cationic morpholino-phthalocyanines conjugated to nitrogen and nitrogen-sulfur doped graphene quantum dots against MCF-7 breast cancer cell line in vitro [PDF]

, 2021
In this work, we explore the reactive oxygen species (ROS) generation abilities of cationic morpholino-substituted-phthalocyanine (Pc) conjugated to nitrogen (NGQDs) and nitrogen-sulfur (NSGQDs) doped-graphene quantum dots upon irradiation with light for
Nene, Lindokhule Cindy, Nyokong, Tebello
core   +2 more sources

Quantum Dots for Biomedical Biosensing, NIR‐II Bioimaging, and Phototherapy: Materials Design, Signal Transduction, and Translational Barriers

Advanced Science, EarlyView.
This review outlines bottom‐up and biomimetic fabrication strategies of quantum dots, and highlights their emerging applications in biosensing, multimodal bioimaging, and intelligent cancer theranostics. It further discusses key translational barriers and future perspectives for advancing QD‐based nanomedicine toward clinical implementation.
Jie Ju, Zhifang Liu, Xinran Gao, Wen Sun, Wei Fu, Yanfei Wang   +5 more
wiley   +1 more source

Transformable Tumor Microenvironment‐Responsive Oxygen Vacancy‐Rich MnO2@Hydroxyapatite Nanospheres for Highly Efficient Cancer Sonodynamic Immunotherapy

Advanced Science
Despite the promise of sonodynamic therapy (SDT)‐mediated immunotherapy, the anticancer efficacy of current sonosensitizers is greatly limited by the immunosuppressive tumor microenvironment (TME) and their inability to selectively respond to it. Herein,
Minxing Li, Qiyu Liu, Songzuo Xie, Desheng Weng, Jinjun He, Xinyi Yang, Yuanyuan Liu, Jinqi You, Jinghao Liao, Peng Wang, Xihong Lu, Jingjing Zhao   +11 more
doaj   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Composite materials for multimodal sonodynamic therapy in biomedical applications

Next Materials
Sonodynamic therapy (SDT) presents significant advantages, such as improved tissue penetration, non-invasiveness, and reduced susceptibility to drug resistance, positioning it as a promising modality in the biomedical domain.
Min Ma, Lili Luo, Yuxuan Ding, Jiayi Zuo, Xiaofen Chai, Libing Liu   +5 more
doaj   +1 more source

Microbubbles Ultrasonic Cavitation Regulates Tumor Interstitial Fluid Pressure and Enhances Sonodynamic Therapy

Frontiers in Oncology, 2022
Sonodynamic therapy (SDT) is a promising treatment method for solid tumors. However, the high interstitial fluid pressure (IFP) in tumor tissues limits the accumulation of sonosensitizers. In the present study, microbubbles ultrasonic cavitation was used
Fen Xi, Fen Xi, Fen Xi, Yuyi Feng, Yuyi Feng, Qiaoli Chen, Qiaoli Chen, Liping Chen, Liping Chen, Jianhua Liu, Jianhua Liu, Jianhua Liu   +11 more
doaj   +1 more source

An Oral Nanomedicine Elicits In Situ Vaccination Effect against Colorectal Cancer [PDF]

, 2023
Oral administration is the most preferred approach for treating colon diseases, and in situ vaccination has emerged as a promising cancer therapeutic strategy.
Kundu, Subhas C., Liu, Jinyao, Ma, Ya, Pan, Guoqing, Reis, Rui L., Shahbazi, Mohammad Ali, Sun, Jianfeng, Xiao, Bo, Zhang, Jun, Zu, Menghang   +9 more
core   +1 more source