Results 131 to 140 of about 687,720 (321)

Comparative Efficacy and Safety of Anakinra and Canakinumab in Patients With VEXAS Syndrome: An International Multicenter Study

open access: yesArthritis &Rheumatology, EarlyView.
Objective The aim of this study was to compare differences in clinical response, drug survival, and adverse event rates between anakinra and canakinumab in VEXAS (vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic) syndrome. Methods This multicenter international study includes patients with VEXAS from France, Israel, and Italy treated with ...
Tali Eviatar   +35 more
wiley   +1 more source

Effect of Time to Start of Biologic Therapy on Treatment Response in Childhood Arthritis: Results From the UCAN CAN‐DU Cohort

open access: yesArthritis &Rheumatology, EarlyView.
Objective To estimate the effect of time from symptom onset to start of biologic treatment on achieving inactive arthritis within six months in a cohort of patients with juvenile idiopathic arthritis (JIA). Methods The international UCAN CAN‐DU study prospectively enrolled patients with JIA across Canada and the Netherlands.
Jelleke B. de Jonge   +102 more
wiley   +1 more source

Mismatching Expressions: Spatiotemporal and Kinematic Differences in Autistic and Non‐Autistic Facial Expressions

open access: yesAutism Research, EarlyView.
ABSTRACT Preliminary studies suggest there are differences in the facial expressions produced by autistic and non‐autistic individuals. However, it is unclear what specifically is different, whether such differences remain after controlling for facial morphology and alexithymia, and whether production differences relate to perception differences ...
Connor T. Keating   +3 more
wiley   +1 more source

Historicizing Hagia Sophia: The Conception of Hagia Sophia in Early Classical Ottoman Chronicles (1451–1512)

open access: yesİslam Tetkikleri Dergisi
This study explores the historicization of Hagia Sophia in the early classical Ottoman chronicles and examines how its perception evolved in the half century following the conquest.
Sedat Akdoğmuş, Bilge Ar
doaj   +1 more source

Valorization of the peel and husk of guaraná (Paullinia cupana): oil extraction, chemical composition, cytotoxicity, and antitumor potential

open access: yesBiofuels, Bioproducts and Biorefining, EarlyView.
Abstract Guaraná (Paullinia cupana) is a fruit native to the Amazon region. Due to its widespread use, primarily in beverages, its production has grown over the years. The seed is the only commercially valuable part of the fruit so the guaraná production chain generates byproducts, including peel, husk, and spent seed.
Leiliane do Socorro Sodré de Souza   +9 more
wiley   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon   +12 more
wiley   +1 more source

Występowanie stulichy psiej (Descurainia sophia (L.) Webb ex Prantl) w uprawach rolniczych na terenie województwa lubelskiego

open access: yesAgronomy Science, 2004
Descurainia sophia belongs to Brassicaceae family. It is a winter or spring annual weed. Flixweed used to be described as a ruderal weed, however, recently it has become, one of the main weed species in the cultivated plants.
Jan Kapeluszny, Małgorzata Haliniarz
doaj  

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul   +7 more
wiley   +1 more source

Career motivations and perceptions of teaching of 16–19‐year‐olds in England and Wales

open access: yesBritish Educational Research Journal, EarlyView.
Abstract The current study provides an understanding of career‐related motivations of 16–19‐year‐olds in schools and A‐level colleges in England and Wales. The 672 participants (62% women) were asked to complete a modified version of the Motivations for Career Choice and the Persistence Research in Science and Engineering scales and provide comments on
Sophie Thompson‐Lee   +4 more
wiley   +1 more source

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