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Genome‐Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology

Movement Disorders, EarlyView.
Abstract Background Recessive genetic variation and extended runs of homozygosity (ROHs) may contribute to the unexplained heritability of Parkinson's disease (PD), particularly in diverse and understudied populations. Objective We conducted the first large‐scale, multi‐ancestral investigation of PD to examine the impact of genome‐wide homozygosity on ...
Kathryn Step +680 more
wiley +1 more source

Patient‐Reported Feedback Suggests an Alternative Sweet Spot for Deep Brain Stimulation Programming in Essential Tremor

Movement Disorders, EarlyView.
(1) To sample subjective patient rating using the Visual Analogue Scale (VAS), random stimulation parameters were presented to the study subjects. (2) Next, corresponding volumes of tissue activated (VTA) were generated and paired with VAS values.
Sophia Peschke +9 more
wiley +1 more source

Increased Serum Neurofilament Light Chain Levels in Parkinson's Disease Patients Carrying the p.A53T SNCA Mutation: Data from the Parkinson's Progression Markers Initiative Study

Movement Disorders, EarlyView.
Abstract Background Serum neurofilament light chain (NfL) levels, a marker of axonal damage, are generally elevated in neurodegenerative conditions, but results in idiopathic Parkinson's disease (iPD) have been inconsistent. The p.A53T SNCA mutation usually leads to a severe form of PD.
Nikolaos Papagiannakis +213 more
wiley +1 more source

A Zosteriform Papular Cutaneous Eruption

JEADV Clinical Practice, EarlyView.
Silvia Borriello +8 more
wiley +1 more source

Single‐Breathhold 3D MR Elastography in the Liver, With Simultaneous R2* and PDFF Mapping

Magnetic Resonance in Medicine, EarlyView.
Purpose To develop a sequence for the rapid acquisition of MR elastography (MRE) parameters in 3D, with simultaneous measurement of proton‐density fat fraction (PDFF) and R2* for multiparametric assessment of liver disease. Methods The proposed sequence uses an interleaved motion‐encoding scheme to acquire 3D volumes of all motion encodings and wave ...
Donovan P Tripp +10 more
wiley +1 more source

Developing Clinical Decision (Support) Systems Combining the Scientific and Regulatory Perspective: European Insights on Challenges, Requirements, and Practical Guidance.

JMIR Med Inform
Vrijlandt SEW +4 more
europepmc +1 more source

An Innovative Approach to Assess Medical Student Perceived Compassionate Communication Skills Before and After High Acuity Simulation Cases. [PDF]

J Med Educ Curric Dev
Subramony R +4 more
europepmc +1 more source

A Framework for Understanding and Evaluating Localization: The Case of HelpAge International

Public Administration and Development, EarlyView.
ABSTRACT Many transnational non‐governmental organizations (TNGOs) are reevaluating their organizational forms and norms as they pursue localization. Localization itself is a contested and multifaceted concept, however, complicating the design, implementation, and evaluation of localization efforts.
Hans Peter Schmitz, George E. Mitchell
wiley +1 more source

Saplings of significance: Nurturing cultural value of new tree plantings through participatory opportunities

People and Nature, EarlyView.
Abstract Tree‐planting initiatives are a crucial part of international sustainability and climate action efforts. Yet, many of these initiatives fail to achieve their long‐term sustainability and climate goals. The role of community value is an often‐overlooked factor in promoting the success of new tree plantings.
Claire L. Narraway +8 more
wiley +1 more source

The dynamics of wild and alternative meat consumption across Gabon, Central Africa

People and Nature, EarlyView.
Abstract Long‐term overharvesting of wild animals for their meat threatens wildlife and the people dependent on wild animal meat for their diets and incomes. Interventions to reduce wild meat consumption must be built upon a complete understanding of the roles of wild meat and its alternatives within food systems.
Joshua Bauld +14 more
wiley +1 more source

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