Results 31 to 40 of about 1,744,388 (246)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A low-cost neural sorting network with O(1) time complexity [PDF]

open access: yes, 2011
[[abstract]]In this paper, we present an O(1) time neural network with O(n1 + var epsilon) neurons and links to sort n data, var epsilon > 0. For large-size problems, it is desirable to have low-cost hardware solutions.
Lin, Shun-Shii;Hsu, Shen-Hsuan
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Spike Sorting Algorithms for Large-Scale Neural Recording [PDF]

open access: yesJisuanji gongcheng
Spike sorting refers to the detection, clustering, and identification of distinct extracellular neuronal signals from different recording sites with the aim of reliably assigning them to different putative neurons.
XU Mingliang, LI Fangyuan, MA Haoran, HE Fei
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

On the use of biased-randomized algorithms for solving non-smooth optimization problems

open access: yes, 2020
Soft constraints are quite common in real-life applications. For example, in freight transportation, the fleet size can be enlarged by outsourcing part of the distribution service and some deliveries to customers can be postponed as well; in inventory ...
Juan A.A.   +4 more
core   +1 more source

An asymmetric approach to preserve common intervals while sorting by reversals [PDF]

open access: yes, 2009
Dias Vieira Braga M, Gautier C, Sagot M-F. An asymmetric approach to preserve common intervals while sorting by reversals. Algorithms for Molecular Biology.
Braga, Marília,   +6 more
core   +1 more source

Optical sorting and manipulation of microscopic particles [PDF]

open access: yes, 2007
Over the last few decades, the use of light to control and manipulate microscopic particles has become widespread. These methods are enabling new areas of research to flourish across the physical and biological sciences.
Milne, Graham
core   +2 more sources

Comparative Analysis of Sorting Algorithms: TimSort Python and Classical Sorting Methods

open access: yesJISA (Jurnal Informatika dan Sains)
The sorted() function within the Python programming language has emerged as the primary choice among developers for sorting operations. Consequently, this study offers a comparative analysis of various classical sorting algorithms and Python's built-in ...
Firmansyah Rekso Wibowo, Muhammad Faisal
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

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