Results 61 to 70 of about 6,864 (176)

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio, Antonio José Martinez‐Mellado, Jonathan Kiwitt‐Cárdenas, José G. Clavel, Bartolomé García‐Perez, Pedro Castro, Maribel Diaz‐Ricart, Andrés Carrillo‐Alcaraz, Amparo López‐Bernús, Enrique Bernal Morell, Aychel Roura, Sonia Marín, Francisco‐José Ruiz‐López, Elena Solana‐Martinez, Domingo Martinez‐Baño, Carlos L. Albacete Moreno, Enriqueta Andreu Soler, Adrián Tellez Santoyo, Sara Fernández Méndez, Jose A. Noguera Velasco, Iria Cebreiros Lopez, Andrés Parrilla, Alberto Espuny‐Miró, David García‐Bernal, Miguel Blanquer, Andrés Sánchez‐Salinas, Francisca Iniesta, Cristina Hernandez Garcia, Manuel Muro, Alfredo Minguela Puras, Antonio Moreno‐Docón, Alberto M. Torres‐Cantero, Maria Munoz Garcia, Manuel Serrano, Massimo Iacobelli, Carmelo Carlo‐Stella, Lee‐Jen Wei, Paul G. Richardson, José M. Moraleda   +38 more
wiley   +1 more source

Third Allogeneic Stem Cell Transplantation in Children: A Multicenter Analysis From the Spanish GETH‐TC Pediatric Group

European Journal of Haematology, EarlyView.
ABSTRACT Third allogeneic hematopoietic stem cell transplantation (HSCT3) is rarely performed in pediatric patients and is associated with high toxicity and mortality. Data on outcomes in this setting remain scarce. We conducted a retrospective multicenter study within the Spanish GETH‐TC Pediatric group including 29 children and adolescents who ...
Luisa Sisinni, Sara Vinagre Enríquez, Marta Villalon Herrera, Mercedes Plaza Fornieles, Iván López Torija, Andrea Urtasun Erburu, Laura Alonso García, Alexandra Regueiro García, Maria Trabazo del Castillo, Eduardo J. Bardón‐Cancho, Odelaisy León‐Triana, Carla Miñarro Chacón, José Luís Fuster Soler, Antonio Pérez‐Martínez, Pascual Balsalobre López, Marta Gonzalez‐Vicent, Cristina Díaz de Heredia, on behalf of the GETH‐TC Pediatric Working Group   +17 more
wiley   +1 more source

Family Perspectives on Disappearance: Perceived Contributing Factors and Coping Strategies for Ambiguous Loss

Family Relations, EarlyView.
ABSTRACT Objective This study aimed to examine how families interpret disappearances, to assess their psychological and emotional impact, and to explore perceived support and coping strategies. Background Disappearances are a widespread yet understudied phenomenon with severe psychological consequences for affected families. The uncertainty surrounding
Martina La Gamma, Pilar Flores, Judith Velasco, Reyes Rodríguez, Carlos Bardavío, Manuel Moyano   +5 more
wiley   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

The FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille   +1 more
wiley   +1 more source

Abrogation of SOS mutagenesis by the <i>E. coli</i> OxyR oxidative stress response. [PDF]

mSystems
Gawel D, Oller AR, Betkowska A, Rozwadowski M, Stelmaszczyk W, Massri AJ, Schaaper RM.   +6 more
europepmc   +1 more source

The Epistemic Harms of Botched Apologies for Past Wrongs

Journal of Applied Philosophy, EarlyView.
ABSTRACT Apologies often create expectations of meaningful change and repair. Yet when institutions or states deliver apologies for past wrongs that lack substantive reparative action, they risk deepening, rather than redressing, the harms they acknowledge.
Abraham Tobi
wiley   +1 more source

Species-specific coevolution of RecA-RecN interfaces governs DNA double-strand break repair in Escherichia coli. [PDF]

PLoS Genet
Inoue M, Akanuma G, Hayashi M, Hishida T.   +3 more
europepmc   +1 more source

Measuring success in HS treatment from the physician's and the patient's perspective

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Integrated clinician (HiSCR, IHS4, IHS4‐55, HS‐IGA) and patient (HiSQOL, DLQI) scores, combined with imaging‐based fibrosis and inflammation assessment, redefine treatment success in hidradenitis suppurativa by aligning treat‐to‐target strategies with both inflammatory control and irreversible structural damage.
Georgios Nikolakis, Monika Arenbergerova, Zeljko Mijuskovic, Baoxi Wang, Christos C. Zouboulis   +4 more
wiley   +1 more source

Phenotypic plasticity trade-offs in an age-structured model of bacterial growth under stress. [PDF]

J Math Biol
El Karoui M, Madrid I, Méléard S.
europepmc   +1 more source

Shark preferences: Only subtle effects of electromagnetic field exposure and substrate type on small‐spotted catshark (Scyliorhinus canicula) behaviour

Journal of Fish Biology, EarlyView.
Abstract Offshore wind energy plays a crucial role in the transition to low‐carbon power generation. The expansion of offshore wind farms (OWFs) introduces anthropogenic electromagnetic fields (EMFs) from subsea power cables. Elasmobranchs, including sharks and rays, are sensitive to natural electric and magnetic fields used for navigation and prey ...
Lotte J. Bouwman, Annemiek Hermans, Jeroen Hubert, Reindert Nijland, Henrice Jansen, Jildou Schotanus, Hendrik V. Winter   +6 more
wiley   +1 more source