Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy
Advanced Science, EarlyView.In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao +12 more
wiley +1 more source
A comparative study on acoustical properties using waste recycled porous materials for environmental sustainability. [PDF]
Sci RepSelvaraj VK +5 more
europepmc +1 more source
LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing
Advanced Science, EarlyView.This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang +15 more
wiley +1 more source
Optimization of multi-structural parameters in metamaterials based on the DGN co-simulation method. [PDF]
PLoS OneJin S, Chen F, Bai J, Liu B.
europepmc +1 more source
On a New Acoustic Apparatus: and on Intensified Sound as a Curative Agent [PDF]
, 1879 W. A. McKeown
openalex +1 more source
The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges
Advanced Science, EarlyView.This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li +3 more
wiley +1 more source
Structural Optimization and Performance Analysis of Acoustic Metamaterials with Parallel Unequal Cavities. [PDF]
Materials (Basel)Pan T +9 more
europepmc +1 more source
Rational Design of Inner Ear Drug Delivery Systems
Advanced Science, EarlyView.Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu +5 more
wiley +1 more source
Moving beyond the noise: geospatial modelling of urban sound environments in a sub-Saharan African city. [PDF]
Sci RepClark SN +13 more
europepmc +1 more source