Results 121 to 130 of about 34,525 (261)

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Tunable Sound Absorption via Evanescent‐Wave Coupling in Asymmetric Bilayer Metasurfaces

Advanced Science, EarlyView.
Tunable sound absorption is realized through a bilayer metasurface system governed by evanescent‐wave coupling. This work demonstrates that such evanescent‐wave coupling provides a controllable scattering channel that destructively interferes with the specular reflection.
Pyung Sik Ma, Hyung Jin Lee
wiley   +1 more source

Toward Next‐Generation High‐Speed Communication and Imaging: Solution‐Processed Sb2(S,Se)3/CdS Heterojunction for Ultrafast Self‐Powered Photodetector

Advanced Science, EarlyView.
A high‐quality solution‐processed Sb2(S,Se)3/CdS heterojunction is designed to overcome the intrinsic limitations of conventional photodetectors. The fabricated device achieves an excellent self‐powered performance, including a high responsivity of 0.6 A W−1, an ultrahigh specific detectivity of 7.68 × 1012 Jones, and a wide 3db bandwidth of 175 kHz ...
Xuhua Xiao, Yichao Wang, Jingxuan Bian, Hailong Wang, Yongqiang Wang, Jinpeng Xu, Junwei Chen   +6 more
wiley   +1 more source

Scalable Electrochemical Concrete Fabrication and Closed‐Loop Recycling

Advanced Science, EarlyView.
The electrochemical‐driven recycling strategy establishes a reversible concrete material flow by extracting Ca, Si, Al, and Fe from concrete waste and regenerating functional feedstocks. These reversed products are reassembled into new concrete, which re‐enters service and ultimately returns to waste, enabling a closed‐loop, waste‐origin, and low ...
Hanxiong Lyu, Zhenlin Li, Yang Liu, Lu Zhu, Lucen Hao, Mingxin Shi, Shipeng Zhang, Chi Sun Poon   +7 more
wiley   +1 more source

Stabilizing and Enhancing Remixing-based Unsupervised Sound Source Separation

APSIPA Transactions on Signal and Information Processing
Kohei Saijo, Tetsuji Ogawa
doaj   +1 more source

Ultrasound‐Responsive Engineered Bacteria for Targeted Cancer Therapy: Strategies, Mechanisms, and Applications

Advanced Science, EarlyView.
This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang, Wenjing Xu, Yafang Lu, Huaibin Yu, Zhengbao Zha, Xijun Zhang   +5 more
wiley   +1 more source

Charge‐Acoustic Phonon Coupling Determined Carrier Transport Properties in FAxMA1−xPbBr3 Perovskite Single Crystals

Advanced Science, EarlyView.
This study investigates acoustic phonon‑carrier coupling in FAxMA1−xPbBr3 single crystals using time‑domain Brillouin scattering. The results show that increasing the FA content in FAxMA1−xPbBr3 single crystal reduces both the elastic constant and the intrinsic carrier mobility governed by the acoustic phonon‑carrier coupling.
Wei Zhang, Zheng Zou, Tiehui Wu, Zijie Xiao, Dan Feng, Jianbin Zhong, Xianshao Zou, Ningjiu Zhao   +7 more
wiley   +1 more source

Vehicle Aerodynamic Noise: A Systematic Review of Mechanisms, Simulation Methods, and Bio-Inspired Mitigation Strategies. [PDF]

Biomimetics (Basel)
Zou T, Fu Y, Cao P.
europepmc   +1 more source