Results 51 to 60 of about 10,869 (256)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Packaging Inspiration: Al Qaeda’s Digital Magazine \u3cem\u3eInspire\u3c/em\u3e in the Self-Radicalization Process [PDF]

, 2013
Al Qaeda is today a fragmented organization, and its strategic communication efforts now focus largely on recruiting individuals in the West to carry out “individual jihad” in their home countries. One Al Qaeda–affiliated publication, Inspire, represents
Sivek, Susan Currie
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

“Stripped Sour Water reuse at an Oil Refinery’’. Case Study and an Economical Evaluation.

Port-Said Engineering Research Journal
Many opportunities are studied to decrease the overall water balance to achieve sustainability and water management of the petroleum sector, and this can happen by applying modern methods of conservation/reuse and recycling. Various sources of wastewater are generated in the petroleum oil refineries, and contaminates are the restricting factor of water
Sherif El Sherbini, Marwa shalaby, Ebrahiem Ebrahiem, Hassan Farrag   +3 more
openaire   +2 more sources

The hydrogen sulfide emissions abatement program at the Geysers Geothermal Power Plant [PDF]

The scope of the hydrogen sulfide (H2S) abatement program at The Geysers Geothermal Power Plant and the measures currently under way to reduce these emissions are discussed.
Allen, G. W., Mccluer, H. K.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

COMPARISON BETWEEN STRIPPING AND MEMBRANE TREATMENTS FOR PETROLEUM REFINERY SOUR WATER

, 2018
As refinarias de petróleo apresentam uma grande importância no mercado mundial e tem como função realizar o refino de óleo cru extraído do solo, transformando-o em diversos subprodutos derivados tais como gasolina, querosene, GLP e óleo diesel. Para certas etapas do procedimento de refino, a água é um importante recurso na purificação desses produtos ...
Ferreira, Newton Libanio, Hochheim, Bruno Perri, Lourenço, Felipe Miranda de Oliveira, de Oliveira, Camilla Fernandes, Silva, Airine Talita Lima, Silva, Tassiane Mariano   +5 more
openaire   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Stability of core/shell quantum dots-role of pH and small organic ligands [PDF]

, 2013
The improvement of knowledge about the toxicity and even processability, and stability of quantum dots (QD) requires the understanding of the relationship between the QD binding head group, surface structure, and interligand interaction.
A Katchalsky, AJ Morris-Cohen, AM Derfus, C David, C Kirchner, C Stefano de, C Stefano de, C Stefano de, C-S Yang, Cristiana Franco, DM Aruguete, E Companys, E Hogfeldt, E Rotureau, F Crea, F Wang, H Mattoussi, J Aldana, J Aldana, J Galceran, JA Kloepfer, JH Priester, José P. Pinheiro, JP Pinheiro, KE Knowles, LD Pettit, MI Vučemilović, N Tessler, P Alivisatos, RF Domingos, RF Domingos, RF Domingos, RF Domingos, RM Smith, RM Smith, Rute F. Domingos, S Celebi, S Kim, S Mahendra, SWFMHT Westerflier, T Kiss, V Bagalkot, VI Klimov, W Guo, W Sun, WW Yu, X Michalet, XG Peng, XH Gao   +48 more
core   +3 more sources