Results 11 to 20 of about 703 (93)
Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman +15 more
wiley +1 more source
The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin
Objectives The objective of this study was to elucidate differences in the cumulative incidence of Leucine‐rich repeat kinase 2 (LRRK2) p.Gly2019Ser‐related Parkinson's disease (PD; LRRK2‐PD) between ancestries and countries. Methods We included 922 unrelated p.Gly2019Ser variant carriers (affected = 762 and unaffected = 160) from the Global Parkinson ...
Theresa Lüth +14 more
wiley +1 more source
Operational thermal stability in organic thin‐film transistors is engineered through interfacial chemistry and deposition temperature. By pairing F10‐SiPc with different surface treatments and tuning substrate temperature during deposition, distinct transport regimes emerge, ranging from crystalline, trap‐prone behavior to reversible, thermally ...
Forest St‐Denis‐Weintrager +6 more
wiley +1 more source
Interactive Groupwise Comparison for Reinforcement Learning from Human Feedback
The standard RLHF uses pairwise comparisons and therefore requires a large number of comparisons leading to a high workload. The comparison pairs are suggested by the system and cannot be chosen by the user. Our RLHF approach provides more agency to the user and demands less work: we leverage the user's visual abilities to effectively explore the ...
Jan Kompatscher +4 more
wiley +1 more source
Abstract Objectives The aim of this research is to develop an understanding of the potential for using recycled glass sand as a resource for restoring Louisiana's coastline by testing the effects of exposure of native estuarine fauna to recycled glass sand and other sand treatments in a laboratory environment.
Dave Cooper Campbell +3 more
wiley +1 more source
ABSTRACT Aim Although patient involvement is widely promoted in healthcare policy, there is limited understanding of how healthcare professionals interpret and implement it in practice. This study explores healthcare professionals' perceptions of patient involvement and how their understanding influences interactions with patients, addressing a gap in ...
Frederikke Andsbjerg Johansen +3 more
wiley +1 more source
Abstract Christmas beetles (subfamily Rutelinae, genera Anoplognathus, Calloodes and Repsimus) are an ecologically important and culturally significant group of Australian scarabs, known for their striking appearance and seasonal mass emergences. Over the last decade, anecdotal reports suggest widespread population declines, raising concerns about ...
Tanya Latty +3 more
wiley +1 more source
Our systematic review of 91 peer‐reviewed articles on tree recruitment highlights a research bias toward seedling‐focused studies and reveals a high prevalence of nonsignificant results. We recommend targeted experimental work on seedling treatments, mycorrhizal associations, fertilization, warm stratification, scarification, and chemical treatments ...
Sarah Bürli +2 more
wiley +1 more source
Soils beneath symptomatic and asymptomatic kauri trees were analysed using LAMP, amplicon sequencing, shotgun metagenomics, and PICRUSt2. LAMP detected Phytophthora agathidicida in 39/60 samples, while shotgun metagenomics detected it at low abundance across all samples.
Zoe King +6 more
wiley +1 more source
This study uses comparative chloroplast genomics and morphological analyses to clarify the phylogenetic positions of 10 morphologically similar Impatiens species in southwestern China, providing key taxonomic insights—including describing a new taxon (Impatiens xishuiensis) and proposing revisions—and advancing our understanding of karst‐adapted ...
Qinqin Yong +6 more
wiley +1 more source

