Results 211 to 220 of about 6,654,101 (315)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Characteristics of Plausible Source Cases Responsible for Recent Mycobacterium tuberculosis Transmission, United States, 2018-2022. [PDF]

Emerg Infect Dis
Kammerer S, Flanagan D, Raz K, Shaw T, Wortham J, Talarico S.   +5 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Velocity-Free Acoustic Emission Source Localization for Complex Structures Using Any-Angle Pathfinding Algorithm. [PDF]

Sensors (Basel)
Li D, Dong L, Wang X, Cheng G, Yang L, Zhu W.   +5 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Overview of Impedance Source Networks for Voltage Source Inverters

This paper provides an analytical overview of different impedance sources networks. General classification and main properties of different impedance source networks and their modifications are summarized and ...
Zaķis, Jānis, Husev, Oleksandr, Shults, Tatiana   +2 more
core  

Open Diagnostic Reader (ODR): An affordable, modular 3D-printed platform for standardized imaging and quantitative analysis of rapid diagnostic tests. [PDF]

HardwareX
Rogers E, Qin Z, Rahman Bhuiyan MT, Khan AI, Islam MT, Bhattacharjee P, Nabil IK, Hossain MN, Rashmi TA, Hasan M, Saha TC, Shishir SO, Washif M, Rahman MR, Mahamud I, Shahmanesh M, Hasan T, Hegde S, Qadri F, McKendry RA, Azman AS.   +20 more
europepmc   +1 more source

The Glasgow Fortran Source-to-Source Compiler [PDF]

Journal of Open Source Software, 2018
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Riverscape heterogeneity shapes population diversity for a migratory fish. [PDF]

Ecol Appl
Baldock JR, Rosenthal WC, Al-Chokhachy RK, Campbell MR, Wagner CE, Walters A.   +5 more
europepmc   +1 more source