Results 191 to 200 of about 7,506,424 (310)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Retraction: Chemical characteristics of groundwater and source identification in a coastal city. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Source identification and probabilistic health risk systematic assessment of soil metals and metalloids pollution in a typical coal-industrial city in Weibei, China. [PDF]

Sci Rep
Li X, Kang C, Xi J, Liu M, Zhang J, Yin Z.   +5 more
europepmc   +1 more source

L-identification for sources

, 2006
We consider a DMS $(mathcal U^L,P^L)$ together with a so-called user $vinmathcal U$. All possible {it outputs} $u^L=(u_1,...,u_L)inmathcal U^L$ are encoded by a $q${it -ary source code} $mathcal C$ on $mathcal U$. Thus, every component $u_i$ of $u^L$ is encoded separately.
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Heavy metal enrichments in rural environment soils, pollution dynamics, source identification, and the role of subsurface mineralizations. [PDF]

Sci Rep
Demirela G, Terzi MH, Durgun MB.
europepmc   +1 more source

Amplify your research and mobilize your knowledge with SOURCE

Library and Learning Services Are you seeking new avenues to amplify the reach of your scholarly and creative works and to reach new audiences? Explore how SOURCE: Sheridan’s institutional repository not only preserves your research but also enhances ...
Duguay, Adam
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Study on Dust Storm Pollution and Source Identification in Northwestern China. [PDF]

Toxics
Meng H, Wang F, Bai G, Li H.
europepmc   +1 more source