Results 71 to 80 of about 1,277,548 (269)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Composition and Source of Perfluorinated Compounds in Soil and Waters from the Rural Areas in Eastern China

Yankuang ceshi, 2015
At present, little research on perfluorinated compounds (PFCs) has been carried out in rural areas. To better determine the pollution level and the geographical distribution of PFC in rural areas, soils, surface waters, and groundwaters were collected ...
CHEN Shu, JIAO Xing-chun, GAI Nan, YIN Xiao-cai, PIAO Hai-tao, LU Guo-hui, LI Xiao-jie, RAO Zhu, YANG Yong-liang   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Identifying Key Potential Source Areas for Ambient Methyl Mercaptan Pollution Based on Long-Term Environmental Monitoring Data in an Industrial Park

Atmosphere, 2018
Precise source identification for ambient pollution incidents in industrial parks were often difficult due to limited measurements. Source area analysis method was one of the applicable source identification methods, which could provide potential source ...
Yujie Liu, Qi Yu, Zihan Huang, Weichun Ma, Yan Zhang   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Comprehensive Risk Evaluation of Perfluoroalkyl Substance Pollution in Urban Riverine Systems: Ecotoxicological and Human Health Perspectives

Toxics
This study investigated the spatiotemporal distribution of perfluoroalkyl substances (PFASs) in the Daku River, Taoyuan, with a particular focus on source apportionment and associated ecological and human health risks.
Ferlian Vida Satriaji, Cat Tuong Le Tong, Nelly Marlina, Yan Lin, Nguyen Duy Dat, Ha Manh Bui, Yoshifumi Horie, Jheng-Jie Jiang   +7 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Insight into the Formation of Winter Black Carbon and Brown Carbon over Xi’an in Northwestern China

Toxics
This study evaluates the effectiveness of air pollution control measures in Xi’an, China, by investigating long-term changes in the concentrations, optical properties, and sources of black carbon (BC) and brown carbon (BrC).
Dan Li, Qian Zhang, Ziqi Meng, Hongmei Xu, Peng Wei, Yu Wang, Zhenxing Shen   +6 more
doaj   +1 more source