Results 121 to 130 of about 4,257,415 (292)

Rapid estimation of viral emission source location via genetic algorithm. [PDF]

Comput Mech, 2022
Clemon LM.
europepmc   +1 more source

Shareholders as Principals [PDF]

, 2002
This paper discusses experimental techniques for detecting if there are multiple sources in a duct and obtaining the acoustic characteristics of these sources.
DeMott, Deborah A.
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Acoustic Emission Source Location Using Finite Element Generated Delta-T Mapping. [PDF]

Sensors (Basel), 2022
Yang H, Wang B, Grigg S, Zhu L, Liu D, Marks R.   +5 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

GA-PSO Algorithm for Microseismic Source Location

Applied Sciences
Accurate source location is a critical component of microseismic monitoring and early warning systems. To improve the accuracy of microseismic source location, this manuscript proposes a GA-PSO algorithm that combines the Genetic Algorithm (GA) with ...
Yaning Han, Fanyu Zeng, Liangbin Fu, Fan Zheng   +3 more
doaj   +1 more source

Artificial Seismic Source Field Research on the Impact of the Number and Layout of Stations on the Microseismic Location Error of Mines

Advances in Civil Engineering, 2019
A site experiment is performed herein within a 100 m range using a high-frequency structure activity monitor to explore the impact of different factors on the microseismic source location and analyze the range of influence of the velocity model, number ...
Bao-xin Jia, Lin-li Zhou, Yi-shan Pan, Hao Chen   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Biofilm viscoelasticity and nutrient source location control biofilm growth rate, migration rate, and morphology in shear flow. [PDF]

Sci Rep, 2021
Nguyen H, Ybarra A, Başağaoğlu H, Shindell O.   +3 more
europepmc   +1 more source