Results 81 to 90 of about 4,847,759 (311)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Chicago Summer Institute 2013 - Evaluating Sources

open access: yes, 2013
Why Sources Matter -- Spring 2012A PDF file of PowerPoint slides for the lesson "Why Sources Matter." Topic include: judging the reliability of sources, evaluating sources, independent sources, self-interested sources, multiple sources, single sources ...
Stony Brook University. School of Journalism. Center for News Literacy.
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Ælfric's hagiographic sources and the Latin legendary preserved in B.L. MS Cotton Nero E i + CCCC MS 9 and other manuscripts

open access: yes, 1980
The attention which has recently been devoted to Ælfric's dependence on large collections of Latin writings for his homiletic sources is in this study extended to hagiographic texts through an examination of the relationship between the sources of Ælfric'
Zettel, Patrick H.
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Chicago Summer Institute 2013 - Why Sources Matter

open access: yes, 2013
Evaluating Sources Student Slides Handout -- Fall 2013Student handouts for the lecture "Why Sources Matter." Topics include: IMVAIN, news outlets, news sources, reliability of sources, independent sources, self-interested sources, authoritive sources ...
Stony Brook University. School of Journalism. Center for News Literacy.
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Quel avenir pour un retour aux sources ? De l’identité des Sources Chrétiennes

open access: yes, 2018
Une version adaptée du texte est parue dans S. ZOUMBOULAKIS, P. SALEMBIER (éd.), Sources Chrétiennes. Ἑλληνική καί λατινική συμβολή στόν εὐρωπαϊκό πολιτισμό, Apport grec et latin à la culture européenne, Athènes, éd. Artos Zois, 2019, p.
Bady, Guillaume
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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