Results 241 to 250 of about 581,893 (315)

Targeting the Notch1‐YY1‐ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T‐Cell‐Driven Cancer Cell Pyroptosis

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), aberrantly activated Notch1 signaling induces its target gene YY1, which impairs immunotherapy efficacy by suppressing tumor cell‐ICAM1‐driven T cell activation and the mediated pyroptosis of T cells against tumor cells.
Ke Zhu, Fa‐Peng Zhang, Chao Qin, Zhi‐Xiao Song, Cai‐Ni Yang, Shu‐Sheng Lin, Xian‐Huan Yu, Wen‐Rui Wu, Chao‐Qun Liu, Chao Liu, Lei‐Bo Xu   +10 more
wiley   +1 more source

GROWING ENMITY BETWEEN THE US AND CHINA: IMPLICATIONS FOR SOUTH ASIA

, 2020
Samia Majeed Hashmi
openalex   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Study on variation characteristics of shear strength of deep-sea sediments in the South China sea under thermo-hydraulic coupling. [PDF]

Sci Rep
Feng Y, Chen Q, Wu L, Tang J, Liu G, Wang Z, Hu W, Chen B, Liu S.   +8 more
europepmc   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

A new <i>Hemicyclops</i> (Copepoda, Cyclopoida, Clausidiidae) associated with the scleractinian coral <i>Galaxea</i> from the South China Sea. [PDF]

Zookeys
Kim IH, Wang J, Ivanenko VN.
europepmc   +1 more source

Species and Phylogenetic Diversity of Woody Plants Shift With the Elevational Gradient in Subtropical Forests in South China. [PDF]

Ecol Evol
Li J, Luo Y, Chen F, Hu C, Xu C, Zhang Z, Hu G.   +6 more
europepmc   +1 more source

Early evidence for pig domestication (8,000 cal. BP) in the Lower Yangtze, South China. [PDF]

Proc Natl Acad Sci U S A
Wang J, Tang Y, Zheng Y, Jiang L, Ma X, Hou Y, Sun G.   +6 more
europepmc   +1 more source

Genetic Diversity and Population Structure of <i>Acanthopagrus latus</i> in the South China Sea. [PDF]

Animals (Basel)
Sun CH, Zhang Q, Lu CH.
europepmc   +1 more source