Results 41 to 50 of about 5,393,657 (299)

Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy

Journal for ImmunoTherapy of Cancer, 2022
Background Immune checkpoint inhibitors (ICI) have radically changed cancer therapy, but most patients with cancer are unresponsive or relapse after treatment. MK-5890 is a CD27 agonist antibody intended to complement ICI therapy. CD27 is a member of the
David Rosen, Laurence Fayadat-Dilman, Yiwei Zhang, Konstantin Dobrenkov, Elliot Chartash, Richard Wnek, Smita Mauze, Hans van Eenennaam, Judith Stammen-Vogelzangs, Ying Yu, Marco Guadagnoli, Lars Guelen, Thierry O Fischmann, Jerelyn Wong, Nikolina Bąbała, Jozef Wagenaars, Veronica Juan, Winnie Prosise, Maurice Habraken, Imke Lodewijks, Danling Gu, Jeanne Baker, David Lutje Hulsik, Lilian Driessen-Engels, Dan Malashock, Joost Kreijtz, Astrid Bertens, Evert de Vries, Astrid Bovens, Arne Bramer, Sean Troth, Svetlana Sadekova, Andrea van Elsas, Jason K Cheung, Jannie Borst, Amy M Beebe   +35 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Europa etnică O analiză a analogiilor şi contrastelor între Orient şi Occident (Ethnic Europe. An Analysis of the Analogies and Contrasts Between East and West) [PDF]

Polis: Revista de Stiinte Politice, 2013
This article aims at examining two types of similarities and dissimilarities between Central-Eastern Europe and Western Europe – similarities and dissimilarities that scientific literature put forward as analysis grid for the ethnic phenomenon. Romania,
Andreea ZAMFIRA
doaj  

11th Congress of South-East European Studies. Sofia 2015

Colloquia Humanistica, 2015
11th Congress of South-East European Studies. Sofia 2015 The 11th Congress of South-East European Studies took place in Sofia, Bulgaria, between 31 August and 4 September 2015.
Mirella Korzeniewska-Wiszniewska
doaj   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Operational Framework for Large-Scale Power-to-X Plants Fed by Renewable Energies Incorporating BESS and Electrolyzer Degradation

IEEE Access
In this study, a large-scale power-to-X (PtX) plant powered by renewable energy (RE) sources for hydrogen (H2) production is modeled with hourly time resolution.
Seyedamin Valedsaravi, Rob Vegelin, Alejandro Olveira   +2 more
doaj   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Antecedents and firm performance of sustainable technology adoption in the clothing industry: A study based on the technology–organization–environment framework

Sustainable Futures
This study adopts the technology-organization-environment (TOE) framework and hypothesizes necessary conditions to examine the impact of technology characteristics, internal and external stakeholders' roles, and the business environment to facilitate ...
Md Aynul Hoque, Rajah Rasiah, Fumitaka Furuoka, Sameer Kumar, Ziaul Haq Adnan, Noman Hossain Chowdhury   +5 more
doaj   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

Challenges of Guaranteeing Privacy in Pandemic Time

SEEU Review, 2020
The right of citizens to privacy in the Republic of Kosovo is guaranteed under the Law on Personal Data Protection. Moreover, this right is guaranteed by the Constitution (Official Gazette, 2008), which is the highest legal act.
Ebibi Candidate Dashnim
doaj   +1 more source