Results 111 to 120 of about 2,545,324 (298)

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

In Situ Confinement of 0D Halometallates Within Deep Eutectic Solvents: From Systematic Screening to Metal‐Tunable Luminescence for Anti‐Counterfeiting Eutectogels

Advanced Science, EarlyView.
We report photostable, photoluminescent deep eutectic solvents (DESs) powered by in situ‐formed zero‐dimensional (0D) halometallates. Stabilized by microenvironment‐controlling hydrogen bond acceptor (HBA) and donor (HBD) networks, these DESs exhibit vibrant, metal ion‐tunable emission (PLQY = 60.2%).
Jeesu Moon, Minkyu Jung, Woojin Jung, Jaeyune Ryu, Jae‐Seung Lee   +4 more
wiley   +1 more source

Profiles and risk assessment of antibiotic resistome between Qinghai-Xizang Plateau and polar regions

Geography and Sustainability
Antibiotic resistance genes (ARGs) are increasingly recognized as a global public health threat, with glaciers acting as reservoirs for ARGs transported via atmospheric pathways. Warming climate accelerates glacier melting, releasing ARGs into downstream
Zhenzhe Wu, Guannan Mao, Yuan Gou, Mukan Ji, Qingqing Ma, Yongqin Liu   +5 more
doaj   +1 more source

A Cold-Shock Protein from the South Pole-Dwelling Soil Bacterium Arthrobacter sp. Confers Cold Tolerance to Rice. [PDF]

Genes (Basel), 2021
Kim SY, Kim JS, Cho W, Jun KM, Du X, Kim KD, Kim YK, Lee GS.   +7 more
europepmc   +1 more source

Multiferroic‐Centric Materials and Systems Engineering for Battery Applications: An Insight Into Mechanisms, Strategies, and Characterizations

Advanced Science, EarlyView.
Multiferroic order parameters – polarization, magnetization, and ferroelastic strain – are positioned as dynamic design variables for batteries. Their mechanistic roles, practical tuning through fabrication and external fields, and ferroic‐resolved characterization routes are unified into a closed‐loop framework, revealing how coupled ferroic responses
Jiaqi Su, Yanda Zhu, Hao Peng, Manman Li, Xuzihan Zhang, Meixiao Wu, Siyuan Zhang, Yuhan Zeng, Jiwen Liao, Ming Luo, Hetaishan Huang, Yutong Wang, Sean Li, Wenxian Li   +13 more
wiley   +1 more source

Millimeter-wave observations of Euclid Deep Field South using the South Pole Telescope

Astronomy & Astrophysics
Context. The South Pole Telescope third-generation camera (SPT-3G) has observed over 10 000 square degrees of sky at 95, 150, and 220 GHz (3.3, 2.0, 1.4 mm, respectively) and will significantly overlap the ongoing 14 000 square-degree Euclid Wide Survey.
Archipley M., Hryciuk A., Bleem L. E., Kornoelje K., Klein M., Anderson A. J., Ansarinejad B., Aravena M., Balkenhol L., Barry P. S., Benabed K., Bender A. N., Benson B. A., Bianchini F., Bocquet S., Bouchet F. R., Camphuis E., Campitiello M. G., Carlstrom J. E., Cathey J., Chang C. L., Chapman S. C., Chaubal P., Chichura P. M., Chokshi A., Chou T.-L., Coerver A., Crawford T. M., Daley C., de Haan T., Deane R. P., Dibert K. R., Dobbs M. A., Doohan M., Doussot A., Dutcher D., Everett W., Feng C., Ferguson K. R., Fichman K., Floyd B., Foster A., Galli S., Gambrel A. E., Gardner R. W., Ge F., Goeckner-Wald N., Gonzalez A., Grandis S., Greve T. R., Gualtieri R., Guidi F., Guns S., Halverson N. W., Hill R., Hivon E., Holder G. P., Holzapfel W. L., Hood J. C., Huang N., Kéruzoré F., Khalife A. R., Knox L., Korman M., Kuo C.-L., Levy K., Lowitz A. E., Lu C., Lynch G. P., Maniyar A., Martsen E. S., Menanteau F., Millea M., Montgomery J., Nakato Y., Natoli T., Noble G. I., Omori Y., Ouellette A., Pan Z., Phadke K. A., Pollak A. W., Prabhu K., Quan W., Raghunathan S., Rahimi M., Rahlin A., Reichardt C. L., Reuter C., Rouble M., Ruhl J. E., Schiappucci E., Simpson A., Sobrin J. A., Stalder B., Stark A. A., Sulzenauer N., Tandoi C., Thorne B., Trendafilova C., Umilta C., Vieira J. D., Vitrier A., Vizgan D., Wan Y., Weiß A., Whitehorn N., Wu W. L. K., Young M. R., Zebrowski J. A., Zhou D.   +110 more
doaj   +1 more source

A simple technique to reinforce kinked South Pole RAE tracheal tube. [PDF]

J Clin Monit Comput, 2021
Kumar N, Dubey PK, Nupoor N, Kumar A, Haq A.   +4 more
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

In Search of the South Pole

, 2011
In 1911 the world was watching, waiting, hoping, attention focused on a desolate spot at the very end of the earth, as two men raced to conquer the South Pole. A hundred years after Roald Amundsen's triumph and Robert Scott's tragic demise, our fascination with the Antarctic remains as acute as ever.
Lewis-Jones, Huw, Herbert, Kari
openaire  

Improved LOLA elevation maps for south pole landing sites: Error estimates and their impact on illumination conditions

, 2020
M. Barker, E. Mazarico, G. Neumann, David E. Smith, M. Zuber, J. Head   +5 more
semanticscholar   +1 more source