Results 121 to 130 of about 62,062 (265)

Free Phenolic Hydroxyl Groups Govern the Anticancer Activity of α‐Mangostin: A Structure–Activity Relationship Insight

ChemFoodChem, EarlyView.
Free phenolic hydroxyl groups in the chemical structure of the natural xanthone α‐mangostin (MGT) contribute positively to achieving the anticancer profile against murine colon cancer, murine triple negative breast cancer, and human osteosarcoma cancer. ABSTRACT The α‐mangostin (MGT) is a natural xanthone obtained from the pericarp of mangosteen fruit (
Otávio Augusto Chaves, Afonso Santine M. M. Velez, Lívia Stenico, Douglas Chaves de Alcântara Pinto, Debora Decote‐Ricardo, Eliezer Avila Gandra, Marco Edilson Freire de Lima, Carlos Serpa   +7 more
wiley   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Genomic epidemiology reveals the origins and transmission dynamics of chikungunya virus in China. [PDF]

Infect Dis Poverty
Chang W, Zheng M, Jiang Y, Liu G, Chen X, Wang X, Guo Y, Liu L, Feng Y, Xia X.   +9 more
europepmc   +1 more source

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Exploring the Current Tools for Fall Risk Assessment in Older Adults Across Southeast Asia and the Need for Culturally Adapted Models: A Scoping Review. [PDF]

Ther Clin Risk Manag
Dharmansyah D, Rahayuwati L, Pramukti I, Mutyara K.   +3 more
europepmc   +1 more source

Resolving CYP2D6 Structural Complexity with Long‐Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cytochrome P450 2D6 (CYP2D6)‐mediated bioactivation of tamoxifen to endoxifen is a key determinant of therapeutic efficacy in estrogen receptor‐positive breast cancer. In Asian populations, the high prevalence of structurally complex CYP2D6 alleles complicates conventional genotyping, limiting accurate genotype–phenotype correlation.
Usa Boonyuen, Sirinyatorn Talukam, Beatriz Aira C. Jacob, Wayu Matphong, Kamonwan Chamchoy, Onrapak Reamtong, Nuntana Meesiripan, Junya Yamagishi, Matthew Phanchana, Chayanoot Rattadilok   +9 more
wiley   +1 more source

Do interracial friendships increase the odds of having an interracial romantic relationship later in adolescence? [PDF]

J Res Adolesc
Dryburgh NSJ, Cho B, Kline NG, Juvonen J.   +3 more
europepmc   +1 more source

Family's socioeconomic and demographic factors on elements of children's dental and oral health: A scoping review

Clinical and Experimental Dental Research, EarlyView.
Abstract Background Family plays a significant role in children's dental and oral health (DOH) elements, such as children's DOH knowledge and practice, the development of children's dental fear and anxiety (DFA), children's dental visits, and children's DOH status.
Wisnu Fadila, Mugia B. Rahardja, Puguh Prasetyoputra, Anne A. Suwargiani, Yanu E. Prasetyo, Eriska Riyanti   +5 more
wiley   +1 more source

Nursing workforce in Southeast Asia: a scoping review of historical trends, contemporary issues, and regional solutions. [PDF]

BMC Health Serv Res
Abdul Rahman H, Zaim SNN.
europepmc   +1 more source

Autonomous Leadership: How Board Independence Shapes Machine Learning Based Corporate Culture in Thailand

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Corporate culture is a critical driver of corporate social responsibility, shaping how firms internalize sustainability, social and environmental concerns, yet its governance antecedents are less understood. Motivated by the need to understand how governance structures affect organizational values and behavior, we explore the relationship ...
Sirimon Treepongkaruna, Stefano Starita
wiley   +1 more source