Results 21 to 30 of about 2,117 (104)
Allergy, EarlyView.ABSTRACT Background Oral and ocular medications are frequently used in the treatment of allergic rhinitis (AR). As part of the update of the Allergic Rhinitis and its Impact on Asthma (ARIA)‐EAACI guidelines, this manuscript presents the ARIA‐EAACI 2024–2025 recommendations for oral and ocular treatments.
Rafael José Vieira +230 more
wiley +1 more source
Acalabrutinib in Chronic Lymphocytic Leukemia: Pharmacology and Emerging Clinical Perspectives
European Journal of Haematology, EarlyView.ABSTRACT Acalabrutinib, a second‐generation Bruton's tyrosine kinase inhibitor (BTKi), is characterized by enhanced specificity and selectivity for BTK with minimal off‐target effects, offering a significant evolution in the treatment of chronic lymphocytic leukemia (CLL). Its mechanism of action, a covalent binding to Cys481 within the BTK active site,
Gianluca Gaidano, Romano Danesi
wiley +1 more source
Financial Management, EarlyView.ABSTRACT We examine how mergers and acquisitions (M&As) enable firms to adapt to climate policy shocks. Exploiting the adoption of the Nitrogen Oxides (NOx) Budget Trading Program (NBP) across US states as an exogenous shock, we find that firms with NOx‐emitting plants subject to the NBP are more likely to engage in M&As, particularly through vertical ...
Samer Adra +3 more
wiley +1 more source
Circular economy business strategies and public schemes: a game theory‐based survey
International Transactions in Operational Research, EarlyView.Abstract This paper develops a selected survey based on game theory in circular economy (CE) by complementing two perspectives: the CE business strategies and the public schemes (PS) available to implement CE systems. These perspectives are concentrated in six CE business strategies (circular inputs, sharing platforms, product‐as‐a‐service (PaaS ...
Vinay Ramani, Pietro De Giovanni
wiley +1 more source
Review of European, Comparative &International Environmental Law, EarlyView.Abstract Just Energy Transition Partnerships (JETPs) are novel financing mechanisms that encourage coal‐dependent emerging economies to transition away from fossil fuels. JETPs aim to facilitate coal phaseout and transitions to renewable energy through private and public financing.
Francine Hug
wiley +1 more source
Social Policy &Administration, EarlyView.ABSTRACT This article takes an extreme case ‐ the emergency closure of a care home on a Friday evening ‐ to explore how a lack of coordination between national and local stakeholders led to a brutalising experience for frail residents and social care staff.
Shazia Zafar +4 more
wiley +1 more source
Brain Age Estimation on T2‐FLAIR Scans for Application to Multiple Sclerosis
Human Brain Mapping, Volume 47, Issue 5, 1 April 2026.While the brain‐age paradigm has emerged as a promising biomarker of neurodegeneration in multiple sclerosis (MS), most available brain‐age prediction models are based on 3D‐T1w scans, which are not acquired in routine clinical practice. Leveraging a large multicentre collection of scans from healthy controls, we developed an accurate brain‐age ...
Jordan Colman +46 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.ABSTRACT Background Swallowing dysfunction—dysphagia—is a frequent and debilitating symptom in neuromuscular disorders, leading to malnutrition, cachexia, aspiration pneumonia, and death. Identification of the underlying pathophysiological mechanisms is important for diagnosis and treatment.
Rachel Zeng +18 more
wiley +1 more source
Clinical Pharmacology in Drug Development, Volume 15, Issue 3, March 2026.Abstract Givinostat is a class I/II histone deacetylase inhibitor indicated for Duchenne muscular dystrophy (DMD). The study evaluated the effect of therapeutic and supratherapeutic givinostat doses on the QT/QTc interval. Healthy volunteers received each treatment—givinostat hydrochloride monohydrate oral suspension as a therapeutic (100 mg) or ...
Eugenio Mercuri +7 more
wiley +1 more source
Knee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 3, Page 961-970, March 2026.Abstract Purpose To determine the clinical outcomes differences and complications in two comparable groups of patients undergoing computer aided surgery (CAS) and robotic‐assisted (RA) posterior stabilised (PS) total knee arthroplasty (TKA) following functional alignment (FA) principles with tibial pre‐cut at a minimum of 4‐year follow‐up. Methods This
Stefano Seracchioli +5 more
wiley +1 more source