Results 41 to 50 of about 21,124,301 (247)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Space-Time Block Coded Adaptive Modulation Aided OFDM

, 2001
Space-time block codes provide substantial diversity advantages for multiple transmit antenna systems at a low decoding complexity. In this contribution, we investigate the achievable diversity advantages in the context of adaptive modulation aided turbo
Liew, T.H., Hanzo, L.
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Adaptive Bayesian Space-Time Equalisation for Multiple Receive-Antenna Assisted Single-Input Multiple-Output Systems

, 2008
This contribution considers nonlinear space–time equalisation (STE) for multiple receive-antenna induced single-input multipleoutput (SIMO) systems. By exploiting the inherent symmetry of the underlying optimal Bayesian STE solution, a novel symmetric ...
Liu, Sheng, Chen, Sheng, Hanzo, Lajos
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Near-Instantaneously Adaptive Cooperative Schemes based on Space-Time Block Codes and V-BLAST

, 2007
In this paper we propose two adaptive schemes for improving the achievable throughput of cooperative diversity aided wireless networks. These schemes are capable of accommodating the channel signal-to-noise ratio (SNR) variation of wireless systems by ...
Zummo, S., El-Hajjar, M., Hanzo, L.
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Adaptive space-time equalisation for multiple-antenna assisted multiple-input multiple-output systems

, 2005
This paper investigates an adaptive space-time equalisation (STE) assisted multiuser detection scheme for multiple-antenna aided multiuser systems. A minimum bit error rate (MBER) design is compared with the standard minimum mean square error (MMSE ...
Livingstone, A., Chen, S.
core   +1 more source