Results 91 to 100 of about 1,611 (240)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Low‐complexity de‐mapping algorithms for 64‐APSK signals

open access: yesETRI Journal, 2019
Due to its high spectrum efficiency, 64‐amplitude phase‐shift keying (64‐APSK) is one of the primary technologies used in deep space communications and digital video broadcasting through satellite‐second generation.
Junwei Bao   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Power Domain Hybrid Modulation-Based Coherent Optical Transmission with Successive Interference Cancelation

open access: yesPhotonics
The 6G era necessitates advanced multiplexing techniques that fully utilize various physical dimensions, including time, frequency, polarization, and space to enhance the achievable bitrate per wavelength and satisfy growing demands for capacity and ...
Xiaoling Zhang, Yong Geng
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Differential Space-Time Coding Scheme Using Star Quadrature Amplitude Modulation Method

open access: yesEURASIP Journal on Advances in Signal Processing, 2006
Differential space-time coding (DSTC) has received much interest as it obviates the requirement of the channel state information at the receiver while maintaining the desired properties of space-time coding techniques. In this paper, by introducing star
Bi Guangguo, Yu Xiangbin, Xu DaZhuan
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Machine Learning–Based Multiparameter Performance Predictions of Ultra-Dense WDM FSO–FTTx Systems Under Diverse Weather Conditions

open access: yesInternational Journal of Optics
Free-space optical (FSO) communication is vital for modern wireless systems due to its high data rates, energy efficiency, secure transmission, and cost-effectiveness.
Ashenafi Paulos Forsido   +2 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

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