Results 111 to 120 of about 6,544,337 (290)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Review of U.S. Human Space Flight Plans Committee
, 2010 This website contains information about the Review of U.S. Human Space Flight Plans Committee including their final report from October 2009. Acourding to their "About" page, "[t]he "Review of United States Human Space Flight Plans" is to examine ...
United States. National Aeronautics and Space Administration. Review of U.S. Human Space Flight Plans Committee.
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
La Escuela como Opción y Espacio: Un Análisis desde las Concepciones y Creencias
Areté, 2017 El trabajo tiene como objetivo sistematizar, a partir de las diferentes posturas y experiencias, la diversidad de concepciones y creencias que se tienen del quehacer educativo en una escuela de Educación Media, orientada bajo la modalidad de Educación ...
Gilberto N. Aranguren Peraza
doaj
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Specific Featuires of Spacial Diffusion in Organic Agriculture
Вестник Российского экономического университета имени Г. В. ПлехановаThe article substantiates the hypothesis of conformity of organic agriculture proliferation in Russia and key provisions of Hagerstrand theory of innovation diffusion.
D. G. Galkin
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source