Results 131 to 140 of about 9,935 (206)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

The Rise of Telemedicine in Orthopaedic Trauma Follow-Up Care and Its Long-Term Outcomes: A Narrative Review. [PDF]

Cureus
Mohamed A, Elasad A, Fuad U, Pengas IP, Abdelazim M.   +4 more
europepmc   +1 more source

Populism and policy capacity: Evidence from an opposition municipality in Istanbul

Public Administration and Development, EarlyView.
Abstract Despite achievements in its conceptual rigor, policy capacity still represents a relatively depoliticized concept that fails to sufficiently consider the ways in which politics plays a role in its creation, mobilization, or decay. This article seeks to contribute to this debate by investigating the impact of populism on policy capacity, the ...
Ebru Ertugal, Faik Gür, İnan Sevinç
wiley   +1 more source

Efficient Extraction of Synovial Chondromatosis Utilizing the Loose Body Vacuum. [PDF]

Video J Sports Med
Cervantes JE, Hu E, Boden SA, Nho SJ.
europepmc   +1 more source

The Concept of Allocation of Certain Risk and its Construction in the Formulation of National Legislation on Liability in Outer Space Activities

Proceedings of the Social and Humaniora Research Symposium (SoRes 2018), 2019
openaire   +1 more source

State Capacity and Path Dependence in Cape Verde's Supreme Audit Institution

Public Administration and Development, EarlyView.
ABSTRACT This study examines state capacity and path dependence in the Supreme Audit Institution (SAI) of Cape Verde, focussing on the performance and governance of the Court of Auditors. Drawing on a mixed‐methods longitudinal design covering the period from 2010 to 2024, the analysis combines international governance indicators, documentary analysis,
Ana Lúcia Romão
wiley   +1 more source

Will AI Replace Physicians in the Near Future? AI Adoption Barriers in Medicine. [PDF]

Diagnostics (Basel)
Obuchowicz R, Piórkowski A, Nurzyńska K, Obuchowicz B, Strzelecki M, Bielecka M.   +5 more
europepmc   +1 more source

Saplings of significance: Nurturing cultural value of new tree plantings through participatory opportunities

People and Nature, EarlyView.
Abstract Tree‐planting initiatives are a crucial part of international sustainability and climate action efforts. Yet, many of these initiatives fail to achieve their long‐term sustainability and climate goals. The role of community value is an often‐overlooked factor in promoting the success of new tree plantings.
Claire L. Narraway, Eline van Remortel, Sophie B. Cowling, Divya Kumar, Hanna Mroczka, Emilija Rudzinskaite, Georgina Sturgeon, Sasha Woods, Daniel B. Hayhow   +8 more
wiley   +1 more source

Interaction between Neighborhood Exposome and Genetic Risk in Child Persistent Distressing Psychotic-like Experiences. [PDF]

Nat Ment Health
Chen Y, Yuan Q, Dimitrov L, Risk B, Ku B, Huels A.   +5 more
europepmc   +1 more source

Integrating artificial intelligence (AI) into colorectal cancer reporting

The Journal of Pathology, EarlyView.
Abstract Artificial intelligence (AI) and deep learning (DL) are transforming cancer research and clinical care, with histopathology playing a central role in this transformation. In colorectal cancer (CRC), the second leading cause of cancer mortality world‐wide, multimodal and vision‐language models (VLMs) hold particular promise for enhancing the ...
Konstantin Bräutigam, Ann‐Marie Baker, Viktor H Koelzer, Jakob N Kather, Trevor A Graham   +4 more
wiley   +1 more source