Results 161 to 170 of about 28,333,951 (294)

Virtual Screening for Dual Inhibitors of HDAC6 and MPO: A Multistep Approach Integrating Chemical Space Analysis and Molecular Docking. [PDF]

ACS Omega
de Viveiros BM, Lima CHS, Romeiro NC.
europepmc   +1 more source

Investing in the health workforce: fiscal space analysis of 20 countries in East and Southern Africa, 2021-2026. [PDF]

BMJ Glob Health, 2022
Asamani JA, Kigozi J, Sikapande B, Christmals CD, Okoroafor SC, Ismaila H, Ahmat A, Nyoni J, Nabyonga-Orem J, Mwinga K.   +9 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Structural diversity and chemical space analysis of a PROTAC database using unsupervised machine learning. [PDF]

Sci Rep
Kharwar A, Marbán-González A, Medina-Franco JL, Velázquez-Martínez CA.   +3 more
europepmc   +1 more source

Financing Comprehensive Immunization Services in Lao PDR: A Fiscal Space Analysis From a Public Policy Perspective. [PDF]

Appl Health Econ Health Policy, 2023
Bahuguna P, Masaki E, Jeet G, Prinja S.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

ANALYSIS OF SPACE ORGANIZATION FOR CIRCULATION : Analysis method of space organization

Journal of Architecture and Planning (Transactions of AIJ), 1998
Shogo ABE, Mineki HATORI, Hiroaki NAKATA
openaire   +2 more sources

Mapping the literature about brain-computer interface in rehabilitation: a graph-theory-based PCA framework for semantic space analysis. [PDF]

Eur J Transl Myol
Coraci D, Regazzo G, Masiero S.
europepmc   +1 more source

Readiness and Challenges of E-Learning during the COVID-19 Pandemic Era: A Space Analysis in Peninsular Malaysia. [PDF]

Int J Environ Res Public Health, 2023
Jafar A, Dollah R, Mittal P, Idris A, Kim JE, Abdullah MS, Joko EP, Tejuddin DNA, Sakke N, Zakaria NS, Mapa MT, Vun Hung C.   +11 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source