Bridging predictive reliability and explainability: a multi-representation deep learning framework for chemical space analysis of immune bioassays. [PDF]
J CheminformJyothy VA +3 more
europepmc +1 more source
Towards the plastome evolution and phylogeny of Cycas L. (Cycadaceae): molecular-morphology discordance and gene tree space analysis. [PDF]
BMC Plant Biol, 2022 Liu J, Lindstrom AJ, Gong X.
europepmc +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Does decentralization of health systems translate into decentralization of authority? A decision space analysis of Ugandan healthcare facilities. [PDF]
Health Policy Plan, 2021 Chen J +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
Comparative Chemical Space Analysis of Pesticides and Substances with Genotoxicity Data. [PDF]
Chem Res ToxicolFoil DH +5 more
europepmc +1 more source
Cardiac Phase Space Analysis: Assessing Coronary Artery Disease Utilizing Artificial Intelligence. [PDF]
Biomed Res Int, 2021 Rabbat MG, Ramchandani S, Sanders WE.
europepmc +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Boundedness and Decay for the Teukolsky Equation on Kerr in the Full Subextremal Range | a | < M : Frequency Space Analysis. [PDF]
Arch Ration Mech AnalShlapentokh-Rothman Y +1 more
europepmc +1 more source