Results 31 to 40 of about 93,935 (305)
AerospaceAccurate prediction of the on-orbit positions of Low Earth Orbit (LEO) satellites is essential for mission success, operational efficiency, and safety.
Yang Guo, Boyang Wang, Zhengxu Zhao
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Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
STar-DETR: A Lightweight Real-Time Detection Transformer for Space Targets in Optical Sensor Systems
SensorsOptical sensor systems are essential for space target detection. However, previous studies have prioritized detection accuracy over model efficiency, limiting their deployment on resource-constrained sensors.
Yao Xiao +5 more
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Bayesian Adaptive Extended Kalman-Based Orbit Determination for Optical Observation Satellites
SensorsAs the number of satellites and amount of space debris in Low-Earth orbit (LEO) increase, high-precision orbit determination is crucial for ensuring the safe operation of spacecraft and maintaining space situational awareness.
Yang Guo +6 more
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Dynamic Simulation of Space Debris Cloud Capture Using the Tethered Net
Space: Science & Technology, 2021 Space debris, especially the space debris cloud, has threatened severely the safety of future space missions. In the framework of multibody system dynamics, a computational approach is proposed in this study to investigate the dynamics of net deployment ...
Qingtao Wang, Dongping Jin, Xiaoting Rui
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
An axiomatic system engineering design method based on NSGA-II algorithm applied to complex systems
Scientific ReportsThis study proposes an integrated framework that combines Axiomatic Design with Model-Based Systems Engineering, incorporating NSGA-II as an intelligent optimization engine. The framework constructs a multi-level traceability matrix linking requirements,
Xiaoqian Zhang +7 more
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Autophagosome marker, LC3, is released extracellularly via several distinct pathways
FEBS Open Bio, EarlyView.This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito +3 more
wiley +1 more source
SPACE DEBRIS, ANOTHER ENVIRONMENTAL ISSUE [PDF]
Challenges of the Knowledge Society, 2022 Space debris is defunct artificial objects in space which no longer serve a useful function (nonfunctional spacecraft and abandoned launch vehicle stages, mission-related debris, and particularly numerous in Earth orbit, fragmentation debris from the ...
Ioana PĂDURARIU
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