Results 171 to 180 of about 247,098 (313)

Bioprinted Tumor Microenvironment Models Reveal Immune Evasion and Guide CAR‐NK Therapeutic Strategies

Advanced Science, EarlyView.
This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim, Seona Jo, In‐Hwan Jang, Yu‐Jin Kim, Youngmee Jung, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Kangwon Lee, Tae‐Don Kim, Su A Park   +10 more
wiley   +1 more source

An improved YOLOv11 network for marine debris detection in underwater environment. [PDF]

Sci Rep
Yuanwei J, Yijiang D, Xuemei W, Khairuddin ASM.   +3 more
europepmc   +1 more source

High energy laser sources for space debris detection

, 2014
The large and rising number of space debris particles in low earth orbit (LEO) is posing an increasing danger to LEO satellites and the ISS. For example, even sub-centimeter particles can cause significant damage to solar panels; cm-class objects can ...
Speiser, Jochen, Sauder, Daniel, Kolbe, Daniel   +2 more
core  

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Physics-Informed Side-Scan Sonar Perception: Tackling Weak Targets and Sparse Debris via Geometric and Frequency Decoupling. [PDF]

Sensors (Basel)
Yu B, Lin R, Zhou H, Zhang J, Zhang X.
europepmc   +1 more source

A frame correlation and Kalman filtering algorithm for space debris detection

, 2014
An algorithm with frame correlative detection and Kalman filtering tracking was proposed to detect the multiple space debris in the optical astronomical images. It can reduce the large amount of calculation of sequential images.
Song, Zongxi, Wen, Desheng, Kang, Menghua, Lu, Hao, Gao, Wei, Mou, Jiao, Xi, Jiangbo, Pang, Peng   +7 more
core  

Space Debris Observation, Detection and Evaluation

The Journal of Space Technology and Science, 2009
KUROSAKI, Hirohisa, NAKAJIMA, Atsushi, MATSUBARA, Emi, YAMAGIWA, Yoshiki   +3 more
openaire   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Observations of Exocomets. [PDF]

Space Sci Rev
Korth J, Norazman A, Bendahan-West R, Kennedy G, Madurga Favieres C, Iglesias D, Shubina O, Xu S, Roth NX.   +8 more
europepmc   +1 more source