Results 141 to 150 of about 11,957,490 (337)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Method for calculating uplift of shield tunnels subjected to underlying grouting in soft clayey ground

open access: yesYantu gongcheng xuebao
Grouting in the underlying strata is a common remedial measure for the excessive settlement of shield tunnels. In the case of structured soft clays, the grouting process induces dissipation of the excess pore pressure in the surrounding strata, which ...
MENG Fanyan 1, 2, 3, JIA Qi 1, 2, 3, CHEN Renpeng 1, 2, 3, CHEN Tong 1, 2, 3, CHENG Hongzhan 1, 2, 3
doaj   +1 more source

Locuinţa individuală pe teren îngust - o soluţie pentru perioada de criză [PDF]

open access: yesUrbanism. Arhitectura. Constructii, 2012
The approach to minimal land lots shows how a reduced area of terrain can be utilized to create an efficient, high-density version of the single-family dwelling while maintaining a decent rapport between built and construction-free areas.
Anca Mihaela Constantin
doaj  

Potential high efficiency solar cells: Applications from space photovoltaic research [PDF]

open access: yes
NASA involvement in photovoltaic energy conversion research development and applications spans over two decades of continuous progress. Solar cell research and development programs conducted by the Lewis Research Center's Photovoltaic Branch have ...
Flood, D. J.
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

High-efficiency 20 GHz traveling wave tube development for space communications [PDF]

open access: yes
A 75 watt CW high efficiency helix TWT operating at 20 GHz was developed for satellite communication systems. The purpose was to extend the performance capabilities of helix TWTs by using recent technology developments.
Aldana, S. L., Tamashiro, R. N.
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Exploring Bayesian network model with noise filtering for rainfall-induced landslide susceptibility assessment in Fujian, China

open access: yesFrontiers in Earth Science
Machine learning models have been increasingly popular in landslide susceptibility mapping based on the correlations among landslides and their inducing factors. However, mislabeled data in model training sets would deteriorate model accuracy. This study
Suhua Zhou   +8 more
doaj   +1 more source

Design requirements for high-efficiency high concentration ratio space solar cells [PDF]

open access: yes
A miniaturized Cassegrainian concentrator system concept was developed for low cost, multikilowatt space solar arrays. The system imposes some requirements on solar cells which are new and different from those imposed for conventional applications.
Patterson, R., Rauschenbach, H.
core   +1 more source

Space-Efficient Graph Kernelizations

open access: yes
Let $n$ be the size of a parameterized problem and $k$ the parameter. We present kernels for Feedback Vertex Set, Path Contraction and Cluster Editing/Deletion whose sizes are all polynomial in $k$ and that are computable in polynomial time and with $O(\rm{poly}(k) \log n)$ bits (of working memory).
Frank Kammer, Andrej Sajenko
openaire   +2 more sources

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