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In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Crowd Management in Open Spaces
Crowd analysis and management is a challenging problem to ensure public safety and security. For this purpose, many techniques have been proposed to cope with various problems. However, the generalization capabilities of these techniques is limited due to ignoring the fact that the density of crowd changes from low to extreme high depending on the ...
Tauseef Ali, Ahmed B. Altamimi
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Exploring the Multifaceted Landscape of Space Industry Applications: Thematic Analysis of Strategic Policy Plans of Developed and Developing Countries [PDF]
In recent decades, the exploration and use of space has transformed from a mere scientific curiosity to a cornerstone of technological innovation.
Arash Hashemi +7 more
doaj +1 more source
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Enhancing Space Management through Digital Twin: A Case Study of the Lazio Region Headquarters
Digital Twin is becoming an increasingly powerful resource in the field of building production, replacing traditional processes in the Architecture, Engineering, Construction and Operations sector.
Giuseppe Piras +2 more
doaj +1 more source
Developed within ESA’s SSA and Space Safety Programme (S2P), the Expert Centre for Space Safety provides subject matter expertise and operational services to coordinate SST data acquisition by a multitude of diverse sensors.
Rodriguez, Julian +6 more
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Space-Based Earth Observations for Disaster Risk Management [PDF]
As space-based Earth observations are delivering a growing amount and variety of data, the potential of this information to better support disaster risk management is coming into increased scrutiny.
Lopez, T. +9 more
core +1 more source
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Space assets and technology for bushfire management [PDF]
The financial, emotional, and ecological impacts of bushfires can be devastating. This report was prepared by the participants of the Southern Hemisphere Space Studies Program 2021 in response to the topic: “How space assets and technologies can be ...
Siddharth Rajput +31 more
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