Results 41 to 50 of about 761,692 (315)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Crowd Management in Open Spaces

open access: yesCoRR, 2019
Crowd analysis and management is a challenging problem to ensure public safety and security. For this purpose, many techniques have been proposed to cope with various problems. However, the generalization capabilities of these techniques is limited due to ignoring the fact that the density of crowd changes from low to extreme high depending on the ...
Tauseef Ali, Ahmed B. Altamimi
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Exploring the Multifaceted Landscape of Space Industry Applications: Thematic Analysis of Strategic Policy Plans of Developed and Developing Countries [PDF]

open access: yesعلوم، فناوری و کاربردهای فضایی
In recent decades, the exploration and use of space has transformed from a mere scientific curiosity to a cornerstone of technological innovation.
Arash Hashemi   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Enhancing Space Management through Digital Twin: A Case Study of the Lazio Region Headquarters

open access: yesApplied Sciences
Digital Twin is becoming an increasingly powerful resource in the field of building production, replacing traditional processes in the Architecture, Engineering, Construction and Operations sector.
Giuseppe Piras   +2 more
doaj   +1 more source

European Expert Centre for Space Safety providing services and support for space surveillance and traffic management.

open access: yes, 2023
Developed within ESA’s SSA and Space Safety Programme (S2P), the Expert Centre for Space Safety provides subject matter expertise and operational services to coordinate SST data acquisition by a multitude of diverse sensors.
Rodriguez, Julian   +6 more
core  

Space-Based Earth Observations for Disaster Risk Management [PDF]

open access: yes, 2020
As space-based Earth observations are delivering a growing amount and variety of data, the potential of this information to better support disaster risk management is coming into increased scrutiny.
Lopez, T.   +9 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Space assets and technology for bushfire management [PDF]

open access: yes, 2021
The financial, emotional, and ecological impacts of bushfires can be devastating. This report was prepared by the participants of the Southern Hemisphere Space Studies Program 2021 in response to the topic: “How space assets and technologies can be ...
Siddharth Rajput   +31 more
core  

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