Results 41 to 50 of about 102,518 (199)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Microstructural and mechanical property gradients along the thickness direction of plasma arc welded thick aluminum alloy plate joints

Hanjie xuebao
To address the issue of insufficient strength in weld joints of thick aluminum alloys, a variable polarity plasma arc-tungsten inert gas (VPPA-TIG) composite welding process was proposed. The welding quality of VPPA-TIG composite welding was validated by
Pengtian ZHANG, Xiaowei WANG, Kang GONG, Hengyi ZHANG, Nan JIANG, Yantao SUI   +5 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Subaperture Imaging Algorithm for Squinted Automotive FMCW SAR Based on CLOSI-Omega-K

IEEE Access
Due to the short duration of automotive frequency-modulated continuous-wave (FMCW) synthetic aperture radar (SAR), targets located at the edge of the imaging scene are often distorted in the SAR image, rendering conventional imaging algorithms ...
Letian Zeng, Yuanyuan Huai, Sheng Zhang, Qi Mao, Yunhuai Zou   +4 more
doaj   +1 more source

Design and Fabrication of Spool Type Pin Puller Mechanism- from Concept to Qualification Model [PDF]

فصلنامه علوم و فناوری فضایی, 2016
In this article the design and the development of spool type pin puller mechanism from concept model to engineering model was expressed. At first, present models and designs were investigated and the conceptual design was based on positive aspects of ...
Ashkan Mahmoud-Aghdami, Farhad Farhang Laleh, Mohammad Ghahramani   +2 more
doaj  

Strategic facility & space planning utilising Design for Lean Six Sigma

International Journal of Sustainable Engineering, 2023
This study aims to develop and implement a Strategic Facility Planning process at a highly regulated manufacturing site to optimise manufacturing space and capacity in a facility running out of space.
Brían Ó Longaigh, John Noonan, Anna Trubetskaya, Olivia McDermott   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A rapid algorithm for millimeter-wave near-field three-dimensional image reconstruction based on FiNUFFT

EURASIP Journal on Advances in Signal Processing
The data to be processed in near-field three-dimensional (3D) imaging is of a considerable volume. The interpolation operation is both time-consuming and introduces interpolation errors, which considerably degrade both accuracy of the imaging and the ...
Letian Zeng, Sheng Zhang, Yuanyuan Huai, Qi Mao, Jingzhao Li, Zhaohui Luo, Yunhuai Zou   +6 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source