Results 51 to 60 of about 92,920 (310)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Frontiers in Genetics, 2021 It is a vital task to design an integrated machine learning model to discover cancer subtypes and understand the heterogeneity of cancer based on multiple omics data.
Jian Liu +7 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
IEEE Access, 2020 An improved input shaping (IS) scheme was proposed for the redundantly actuated cable driving parallel robots (CDPRs) to suppress the residual vibration (RV).
Zhengsheng Chen, Xuesong Wang
doaj +1 more source
Case Studies in Thermal Engineering, 2023 In the case of fires in inclined immersed tunnels, smoke flow patterns differ from those of horizontal tunnels, and require a unique approach to lateral centralized smoke exhaust.
Yuyang Ming +7 more
doaj +1 more source
What Do Large Language Models Know About Materials?
Advanced Engineering Materials, EarlyView.If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer +2 more
wiley +1 more source
Engineering Applications of Computational Fluid Mechanics, 2020 The speed of an excavation and suction rescue vehicle (ESRV) can be adjusted by adjusting the opening position/diameter of the vertical suction component in the gas-liquid flow field within the pipe.
Fanbao Chen +4 more
doaj +1 more source
A novel coating technology for fast sealing of air leakage in underground coal mines
International Journal of Mining Science and Technology, 2021 Air leakage in underground coal mines presents a serious hazard for coal production and the safety of miners. Coating technology is commonly used as an efficient means for preventing air leakage. To address existing problems with high dust concentrations
Sihua Shao +7 more
doaj +1 more source
Persistent scatterer interferometry to monitor mining related ground surface deformation for data-driven modelling [PDF]
, 2006 The monitoring, interpretation and prediction of gradual ground surface deformation are critical factors in the understanding of earth systems. In many parts of the world, particularly in coastal areas where resources are often easily transportable and ...
Kemeling, Ilona
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