Results 61 to 70 of about 3,356,206 (287)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Enhancing the accuracy of urban population spatialization at 100-m grid scale through differentiating residential and non-residential buildings

Frontiers in Earth Science
Population grid data have significant implications for socioeconomic development, urban planning, and environmental protection. However, current mainstream gridded population data products (e.g., WorldPop and LandScan) at the 100-m grid scale often fail ...
Mingguang Tu, Qing Ji, Yong Sun
doaj   +1 more source

A Cloud Detection Method Using Convolutional Neural Network Based on Gabor Transform and Attention Mechanism with Dark Channel Subnet for Remote Sensing Image

Remote Sensing, 2020
Cloud detection, as a crucial step, has always been a hot topic in the field of optical remote sensing image processing. In this paper, we propose a deep learning cloud detection Network that is based on the Gabor transform and Attention modules with ...
Jing Zhang, Qin Zhou, Jun Wu, Yuchen Wang, Hui Wang, Yunsong Li, Yuzhou Chai, Yang Liu   +7 more
doaj   +1 more source

Deciphering metasomatic events beneath Mindszentkálla (Bakony-Balaton Highland Volcanic Field, western Pannonian Basin) revealed by single-lithology and composite upper mantle xenoliths

Frontiers in Earth Science, 2022
Single-lithology and composite xenoliths from Mindszentkálla (Bakony-Balaton Highland Volcanic Field) in the Carpathian-Pannonian region record geochemical evolution of the subcontinental lithospheric mantle.
Levente Patkó, Levente Patkó, Levente Patkó, Zoltán Kovács, Zoltán Kovács, Nóra Liptai, Nóra Liptai, László E. Aradi, László E. Aradi, Márta Berkesi, Márta Berkesi, Jakub Ciazela, Károly Hidas, Carlos J. Garrido, István J. Kovács, István J. Kovács, Csaba Szabó   +16 more
doaj   +1 more source

Complex Objects in the Polytopes of the Linear State-Space Process [PDF]

, 2014
A simple object (one point in $m$-dimensional space) is the resultant of the evolving matrix polynomial of walks in the irreducible aperiodic network structure of the first order DeGroot (weighted averaging) state-space process.
Friedkin, Noah E.
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Self-Organizing Neural Network Model for Redundant Sensory-Motor Control, Motor Equivalence, and Tool Use [PDF]

, 1992
A neural network is introduced which provides a solution of the classical motor equivalence problem, whereby many different joint configurations of a redundant manipulator can all be used to realize a desired trajectory in 3-D space.
Bullock, Daniel, Grossberg, Stephen, Guenther, Frank   +2 more
core   +1 more source

A network-based threshold model for the spreading of fads in society and markets

, 2005
We investigate the behavior of a threshold model for the spreading of fads and similar phenomena in society. The model is giving the fad dynamics and is intended to be confined to an underlying network structure.
Barabási A.-L., Erdős P., Holme P., Janson S., Milgram S., Watts D. J.   +5 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source