Results 111 to 120 of about 180,159 (256)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Optical and simulated visual outcomes of two presbyopia-correcting intraocular lenses tested in clinically relevant decentration and tilt conditions. [PDF]

Biomed Opt Express
Cuellar F, Vega F, Madrid D, Alfonso JF, Millan MS.   +4 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Effect of Crystal Structure Anisotropy on the Corrosion Characteristics of Metals in Liquid Lead: A Molecular Dynamics Simulation Study. [PDF]

Materials (Basel)
Liang N, Long B, Ruan Z, Fu X, Zhang X, He Y, Lu S, Chen L.   +7 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Charge Ordering and Incommensurate Modulations in the Metamagnetic Layered Manganese Oxysulfide Sr₂MnO₂Cu_3.5S₃. [PDF]

J Am Chem Soc
Crentsil LE, Rutt OJ, Free DG, David MJ, Smyth RD, Smura CF, Keen DA, Fitch AN, Hadermann J, Clarke SJ.   +9 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Memory-efficient scalable line-based image coding

Proceedings DCC'99 Data Compression Conference (Cat. No. PR00096), 1999
E. Ordentlich, D. Taubman, M. Weinberger, G. Seroussi, M. Marcellin   +4 more
semanticscholar   +1 more source

Mechanical properties of crystalline-amorphous composites: generalization of Hall-Petch and inverse Hall-Petch behaviors. [PDF]

Natl Sci Rev
Xu Z, Li M, Han Y.
europepmc   +1 more source