Results 61 to 70 of about 5,474,703 (294)

Pickup Ion–Mediated Magnetic Reconnection in the Outer Heliosphere

The Astrophysical Journal Letters, 2023
Pickup ions (PUIs) play a crucial role in the heliosphere, contributing to the mediation of large-scale structures such as the distant solar wind, the heliospheric termination shock, and the heliopause.
M. Nakanotani, G. P. Zank, L.-L. Zhao
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Constraints on the Electron Acceleration Process in Solar Flare: A Case Study

Geophysical Research Letters, 2021
Combining in situ measurements of energetic electrons and remote sensing observations of hard X‐rays and type III radio bursts, we examine the release times of energetic electrons in the July 23, 2016 event. We find that the releases of in situ energetic
G. Li, X. Wu, F. Effenberger, L. Zhao, S. Lesage, N. Bian, L. Wang   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Magnetospheric convection electric field dynamics and stormtime particle energization: Case study of the magnetic storm of 4 May 1998 [PDF]

, 2004
International audienceIt is shown that narrow channels of high electric field are an effective mechanism for injecting plasma into the inner magnetosphere. Analytical expressions for the electric field cannot produce these channels of intense plasma flow,
Liemohn, M. W., Newman, T.S., Khazanov, G.V., T. S. Newman, M.-C. Fok, Fok, M.C., Liemohn, M.W., A. J. Ridley, Ridley, A.J., Khazanov, G. V., Newman, T. S., Ridley, A. J., G. V. Khazanov, M. W. Liemohn, Fok, M.-C.   +14 more
core   +2 more sources

Space-Time Structured Plasma Waves

Physical Review Letters
Electrostatic waves play a critical role in nearly every branch of plasma physics from fusion to advanced accelerators, to astro, solar, and ionospheric physics. The properties of planar electrostatic waves are fully determined by the plasma conditions, such as density, temperature, ionization state, or details of the distribution functions.
J. P. Palastro, K. G. Miller, R. K. Follett, D. Ramsey, K. Weichman, A. V. Arefiev, D. H. Froula   +6 more
openaire   +3 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Energy Conversion by Parallel Electric Fields During Guide Field Reconnection in Scaled Laboratory and Space Experiments

Geophysical Research Letters, 2018
We present direct and scaled comparisons between laboratory and in situ space observations of magnetic reconnection with a guide field, comparing results from the Magnetospheric Multiscale Mission and the Magnetic Reconnection eXperiment (MRX).
W. Fox, Victoria Wilder, S. Eriksson, J. Jara‐Almonte, F. Pucci, J. Yoo, H. Ji, M. Yamada, R. E. Ergun, M. Oieroset, T. D. Phan   +10 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source