Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
A Comparative Research on the Facility Criteria of Cities·Provinces Education Office and Space Program of Competition School in Chung-buk Province [PDF]
Donghoon Chang, Jung Jinju
openalex +1 more source
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Emerging Chemical and Biological Materials Technologies in the Extraplanetary Environment. [PDF]
Jiang Q +5 more
europepmc +1 more source
Research of the recombination rate of space charge in LDPE film during the short-circuit discharge process via the photon counting method [PDF]
Chun Xiao +6 more
openalex +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
The Influence of Deep Space and the Stars on Emotions. [PDF]
Martens JP, Prokopetz M, Tomlinson K.
europepmc +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Research on the coupling mechanism between green space morphology and the urban heat island effect based on machine learning: a case study of Dali City, China. [PDF]
Peng J, Zhang S, Li X, Chen R, Huang X.
europepmc +1 more source

