Results 91 to 100 of about 201,227 (357)
Advanced Science, EarlyView.This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang +17 more
wiley +1 more source
Space shuttle pogo studies [PDF]
Topics covered include: (1) pogo suppression for main propulsion subsystem operation; (2) application of quarter-scale low pressure oxidizer turbopump transfer functions; (3) pogo stability during orbital maneuvering subsystem operation; and (4) errors ...
Coppolino, R. N., Lock, M. H., Rubin, S.
core +1 more source
Advanced Science, EarlyView.Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen +8 more
wiley +1 more source
Orbiter structural design and verification [PDF]
The space shuttle development program provided the opportunity to challenge many of the established practices and approaches used in prior manned space flight programs.
Glynn, P. C., Moser, T. L.
core +1 more source
Advanced Science, EarlyView.The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang +15 more
wiley +1 more source
, 2021 My artifact will focus on space shuttle disasters, including the two main United States disasters, including the Space Shuttle Columbia Disaster (2003) and the Challenger Disaster (1986). The events of these infamous days live on in the minds of citizens who became aware that these disasters took multiple American lives.
openaire +1 more source
, 1991 The X-15 established such widespread confidence in aerodynamic, thermal, and structural areas that new designs for operation aircraft for any speed regime could be expected to be successfully achieved if good use was made of all pertinent test facilities
Donlan, Charles J.
core +1 more source
Advanced Science, EarlyView.In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei +9 more
wiley +1 more source
Delta Advanced Reusable Transport (DART): An alternative manned spacecraft [PDF]
Although the current U.S. Space Transportation System (STS) has proven successful in many applications, the truth remains that the space shuttle is not as reliable or economical as was once hoped.
Kosha, M., Lewerenz, T., Magazu, H.
core +1 more source
Advanced Science, EarlyView.Exclusive Se‐O coordination and Fe‐doping complementation significantly improve conductivity and modulate the d‐band centers, which strongly anchor polysulfides in bidirectional catalysis and reduce the energy barriers for the Li2S nucleation and dissociation, achieving high‐apacity retention, exceptional rate capability, and stable cycling capability.
Zhao Yang +6 more
wiley +1 more source