Results 111 to 120 of about 201,227 (357)
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Ground man-machine interfaces for orbiter checkout [PDF]
The challenge of the concept of a reusable, cargo carrying space vehicle, and how those challenges were met for the Space Shuttle are discussed. The complexity of the vehicle, the ground support systen, the onboard computer system, ramifications of a ...
Blackmon, F. H.
core +1 more source
Cathode Electrolyte Interphase Engineering by Quaternized Chitosan for Stabilized Li–SPAN Batteries
Advanced Science, EarlyView.In this work, quaternized chitosan (QCS) is reported as an additive optimizing the sulfurized polyacrylonitrile (SPAN) cathode/electrolyte interphase (CEI). Its high positive charge density adsorbs PF6− anions, enriching the Helmholtz layer with aggregates. This promotes rapid anion desolvation, forming an anion‐derived CEI enriched in LiF.
Runhe He +12 more
wiley +1 more source
Space shuttle rudder/speedbrake actuation subsystem [PDF]
, 1985 The Rudder/Speedbrake (R/SB) Actuation Subsystem for use on the NASA Space Shuttle Orbiter is an electro-hydro-mechanical system which provides the control and positionary capability of the orbiter aero-dynamic primary flight control surface.
Naber, R. A.
core +1 more source
Advanced Science, EarlyView.Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley +1 more source
Manipulator technology for the space shuttle [PDF]
, 1972 A shuttle-attached manipulator is currently proposed as the payload-handling device for the space shuttle. Basic requirements for the manipulator involve length, force, compliance, and control.
Burroughs, E. G.
core +1 more source
Advanced Science, EarlyView.In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia +11 more
wiley +1 more source
Lightning observations from space shuttle [PDF]
The experimental program of the Earth Sciences and Applications Division at NASA/MSFC includes development of the Lightning Imaging Sensor (LIS) for the NOAA Earth Observing System (EOS) Polar Platform.
Boeck, William L.
core +1 more source