Results 151 to 160 of about 201,227 (357)
Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer
Advanced Science, EarlyView.This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo +6 more
wiley +1 more source
Advanced Science, EarlyView.A key challenge in nicotine electroanalysis is the unresolved complexity of its interface process, which directly determines sensor metrics. Herein, the proton‐coupled electron transfer mechanism of nicotine is decoded for multi‐scenario portable electrochemical sensing.
Yi Peng +9 more
wiley +1 more source
Vibration Characteristics of the HPOTP (High-Pressure Oxygen Turbopump) of the SSME (Space Shuttle Main Engine) [PDF]
, 1985 D. W. Childs, David Scott Moyer
openalex +1 more source
Advanced Science, EarlyView.Dissolution and shuttling of TMF cathodes hinders high‐voltage thermal batteries. A novel selective confinement strategy using a sub‐nanoporous COF‐derived carbon interface (0.54 nm pores) on CoF2 suppresses cathode material shuttling. Size‐selective confinement blocks large dissolved ions (∼0.8 nm) while allowing Li⁺ passage, enhancing thermal battery
Mengfan Xu +9 more
wiley +1 more source
Proposed Changes in the Mission Control Jacchia Atmospheric Model [PDF]
The space shuttle orbit prediction program uses the Jacchia Atmospheric model. The errors in the shuttle orbit prediction are investigated by not considering variations in solar flux or geomagnetic ...
Solis, A. J.
core +1 more source
Advanced Science, EarlyView.The strong Cu–O–Ni electronic interaction in the heterostructured catalyst can enhance the effective adsorption of NO3− and accelerate the in situ hydrolysis dissociation of the hydrogenation step. The Zn‐NO3 hybrid battery assembled with this catalyst achieves an open‐circuit voltage of 1.45 V, a peak power density of 6.47 mW cm−2, and can ...
Taozhi Lv +5 more
wiley +1 more source
Revised estimates for ozone reduction by shuttle operation [PDF]
Previous calculations by five different modeling groups of the effect of space shuttle operations on the ozone layer yielded an estimate of 0.2 percent ozone reduction for the Northern Hemisphere at 60 launches per year.
Potter, A. E.
core +1 more source
Advanced Science, EarlyView.This review comprehensively summarizes the atomic defects in TMDs for their applications in sustainable energy storage devices, along with the latest progress in ML methodologies for high‐throughput TEM data analysis, offering insights on how ML‐empowered microscopy facilitates bridging structure–property correlation and inspires knowledge for precise ...
Zheng Luo +6 more
wiley +1 more source
Vibroacoustic and thermal environment data gathered from the first three flights of the space shuttle are presented. The characterization of the particulate, gaseous, and electromagnetic emissions associated with the shuttle flight is emphasized ...
Leger, L. J., Miller, E. R.
core +1 more source
Advanced Science, EarlyView.An anisotropic dual S‐scheme heterojunction (C3N4/SubPc‐1/C3N5) is constructed to overcome the electron–proton kinetics mismatch in photocatalytic H2O2 production. The imide bridge serves as a dual channel for ultrafast electron transfer and proton relay, synergistically enabling efficient dual‐pathway oxygen reduction and achieving a high H2O2 ...
Bing Wang +7 more
wiley +1 more source